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Abstract：
Brain-derived neurotrophic factor (BDNF) plays a functional role in vascular endothelium homeostasis and the alleviation of atherosclerosis. Matrix gla protein (MGP) and Nε-(1-carboxymethyl)-l-lysine (CML) are both confirmed to be VC predictors. This study investigated the association between BDNF, MGP, CML and coronary artery calcification (CAC). Plasma BDNF, MGP, and CML levels were measured in 274 patients who underwent computed tomography to determine the CAC score (Agatston score). It was found that patients with CAC exhibited lower BDNF and MGP and higher CML levels than those without CAC. Plasma BDNF levels in patients with diabetes or hypertension were lower compared with the control groups. In logistic regression analysis, age, hypertension, BDNF, and MGP were independent predictors of CAC. Plasma BDNF and MGP levels were both correlated with the Agatston score even after adjustment for age, total cholesterol level, triglycerides, low-density lipoprotein level, creatinine clearance rate, and the presence of hypertension and diabetes mellitus. In 167 patients with CAC, circulating BDNF level was inversely associated with CML level and positively related to MGP level. In the receiver operating characteristic analysis for CAC, the areas under the curves for BDNF, MGP, and CML were 0.757, 0.777 and 0.653, respectively. In summary, plasma BDNF levels are associated with the Agatston score, and BDNF further predicts the occurrence of CAC.
摘要：
脑源性神经营养因子（BDNF）在血管内皮稳态和动脉粥样硬化的缓解中起功能作用。基质gla蛋白（MGP）和Nε-（1-羧甲基）-1-赖氨酸（CML）均被证实是VC预测因子。本研究调查了BDNF，MGP,CML和冠状动脉钙化(CAC)。血浆BDNF,MGP,我们对274例接受计算机断层扫描的患者进行了CML水平测定,以确定CAC评分(Agatston评分).发现与没有CAC的患者相比，患有CAC的患者表现出更低的BDNF和MGP水平和更高的CML水平。糖尿病或高血压患者的血浆BDNF水平低于对照组。在逻辑回归分析中，年龄,高血压,BDNF,MGP是CAC的独立预测因子。血浆BDNF和MGP水平均与Agatston评分相关，即使调整了年龄，总胆固醇水平,甘油三酯，低密度脂蛋白水平，肌酐清除率,以及高血压和糖尿病的存在。在167例CAC患者中，循环BDNF水平与CML水平呈负相关,与MGP水平呈正相关.在CAC接收机工作特性分析中,BDNF曲线下的面积，MGP,CML分别为0.757、0.777和0.653。总之,血浆BDNF水平与Agatston评分相关，BDNF进一步预测CAC的发生。
