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Abstract：
Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and clinicians, including pathologists, to include collagen fiber evaluation as part of the investigation of cancer development and progression. Fibrillar collagen is the most abundant in the normal extracellular matrix, and was revealed to be upregulated in many cancers. Recent studies suggested an emerging theme across multiple cancer types in which specific collagen fiber organization patterns differ between benign and malignant tissue and also appear to be associated with disease stage, prognosis, treatment response, and other clinical features. There is great potential for developing image-based collagen fiber biomarkers for clinical applications, but its adoption in standard clinical practice is dependent on further translational and clinical evaluations. Here, we offer a comprehensive review of the current literature of fibrillar collagen structure and organization as a candidate cancer biomarker, and new perspectives on the challenges and next steps for researchers and clinicians seeking to exploit this information in biomedical research and clinical workflows.
摘要：
最近的研究强调了关键肿瘤微环境特征的重要性。特别是富含胶原蛋白的细胞外基质（ECM）在表征肿瘤的侵袭和进展。这引起了基础研究人员和临床医生的极大兴趣，包括病理学家,包括胶原纤维评估作为癌症发展和进展调查的一部分。原纤维胶原在正常细胞外基质中含量最丰富，并被发现在许多癌症中上调。最近的研究表明，在多种癌症类型中出现了一个新的主题，其中特定的胶原纤维组织模式在良性和恶性组织之间有所不同，并且似乎与疾病阶段有关。预后,治疗反应,和其他临床特征。有开发基于图像的胶原纤维生物标志物用于临床应用的巨大潜力，但其在标准临床实践中的采用取决于进一步的转化和临床评估。这里,我们提供了一个全面的现有文献的纤维状胶原结构和组织作为一个候选的癌症生物标志物，以及寻求在生物医学研究和临床工作流程中利用这些信息的研究人员和临床医生面临的挑战和下一步的新观点。
