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Abstract：
Plant viruses typically have highly condensed genomes, yet the plant-pathogenic viruses Cassava brown streak virus, Ugandan cassava brown streak virus, and Euphorbia ringspot virus are unusual in encoding an enzyme not yet found in any other virus, the \"house-cleaning\" enzyme inosine triphosphatase. Inosine triphosphatases (ITPases) are highly conserved enzymes that occur in all kingdoms of life and perform a house-cleaning function by hydrolysing the noncanonical nucleotide inosine triphosphate to inosine monophosphate. The ITPases encoded by cassava brown streak virus and Ugandan cassava brown streak virus have been characterized biochemically and are shown to have typical ITPase activity. However, their biological role in virus infection has yet to be elucidated. Here we review what is known of viral-encoded ITPases and speculate on potential roles in infection with the aim of generating a greater understanding of cassava brown streak viruses, a group of the world\'s most devastating viruses.
摘要：
植物病毒通常具有高度浓缩的基因组，然而植物致病病毒木薯棕色条纹病毒，乌干达木薯棕色条纹病毒，和大品红环斑病毒在编码一种尚未在任何其他病毒中发现的酶方面是不寻常的，“清洁房屋”酶肌苷三磷酸酶。肌苷三磷酸酶（ITPases）是高度保守的酶，存在于生命的所有王国中，并通过将非规范的核苷酸三磷酸肌苷水解为肌苷一磷酸来执行房屋清洁功能。木薯棕色条纹病毒和乌干达木薯棕色条纹病毒编码的ITPase已进行了生化鉴定，并显示具有典型的ITPase活性。然而,它们在病毒感染中的生物学作用尚未阐明。在这里，我们回顾了已知的病毒编码的ITPases，并推测在感染中的潜在作用，目的是对木薯棕色条纹病毒有更深入的了解。一组世界上最具破坏性的病毒。
