关键词: Human Connectome Project interthalamic adhesion massa intermedia probabilistic Tractography structural connectivity

来  源:   DOI:10.1002/hbm.25329   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
The role of massa intermedia (MI) is poorly understood in humans. Recent studies suggest its presence may play a role in normal human neurocognitive function while prior studies have shown the absence of MI correlated with psychiatric disorders. There is growing evidence that MI is likely a midline white matter conduit, responsible for interhemispheric connectivity, similar to other midline commissures. MI presence was identified in an unrelated sample using the Human Connectome Project database. MI structural connectivity maps were created and gray matter target regions were identified using probabilistic tractography of the whole brain. Probabilistic tractography revealed an extensive network of connections between MI and limbic, frontal and temporal lobes as well as insula and pericalcarine cortices. Women compared to men had stronger connectivity via their MI. The presented results support the role of MI as a midline commissure with strong connectivity to the amygdala, hippocampus, and entorhinal cortex.
摘要:
massaintermedia(MI)的作用在人类中知之甚少。最近的研究表明,它的存在可能在正常的人类神经认知功能中起作用,而先前的研究表明,MI的缺失与精神疾病有关。越来越多的证据表明MI可能是中线白质导管,负责半球间的连通性,类似于其他中线连发。使用HumanConnectomeProject数据库在不相关的样品中鉴定MI存在。创建MI结构连接图,并使用整个大脑的概率示踪图识别灰质目标区域。概率示踪成像揭示了MI和边缘之间广泛的连接网络,额叶和颞叶以及脑岛和果皮皮质。与男性相比,女性通过MI的连通性更强。提出的结果支持MI作为中线连合的作用,与杏仁核具有很强的连通性,海马体,和内嗅皮层。
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