METHODS: Electromyography was performed on a case of muscle-specific tyrosine kinase antibody positive myasthenia gravis with peripheral nerve hyperexcitability correlated with the administration of pyridostigmine bromide before and after drug withdrawal, respectively.
RESULTS: Afterdischarges close after M waves appeared on the tibial nerve, common peroneal nerve, median nerve, and ulnar nerve, and these presented unique characteristics in repetitive nerve stimulation. Ten days after pyridostigmine bromide withdrawal, the second electromyography examination was carried out and showed that the afterdischarges on all nerves disappeared dramatically and the amplitude of tibial nerve F waves was elevated than before.
CONCLUSIONS: Afterdischarges can be an important indicator of muscle-specific tyrosine kinase antibody positive myasthenia gravis with peripheral nerve hyperexcitability correlated with acetylcholinesterase inhibitors.