PDF(Pubmed)
Abstract：
UNASSIGNED: As of August 23, 2020, the 2019 novel coronavirus disease (COVID-19) has infected more than 23,518,340 people and caused more than 810,492 deaths worldwide including 4,717 deaths in China. We present a case of a 53-year-old woman who was admitted to the hospital because of dry coughs and high fever on January 26, 2020, in Wuhan, China. She was not tested for SARS-CoV-2 RNA until on hospital day 11 (illness day 21) because of a significant shortage of test kits at the local hospital. Then, her test was positive for COVID-19 on hospital day 20. Despite intensive medical treatments, she developed respiratory failure with secondary bacterial infection and expired on hospital day 23 (3 days after she was tested positive for SARS-CoV-2 RNA). A systemic autopsy examination, including immunohistochemistry and ultrastructural studies, demonstrates that SARS-CoV-2 can infect multiple organs with profound adverse effect on the immune system, and the lung pathology is characterized by diffuse alveolar damage. Extrapulmonary SARS-CoV-2 RNA was detected in several organs postmortem. The detailed pathological features are described. In addition, this report highlights the value of forensic autopsy in studying SARS-CoV-2 infection and the importance of clinicopathological correlation in better understanding the pathogenesis of COVID-19.
摘要：
■截至2020年8月23日，2019年新型冠状病毒病（COVID-19）已感染23,518,340多人，在全球造成810492多人死亡，其中中国有4,717人死亡。我们介绍了一名53岁的妇女，她于2020年1月26日在武汉因干咳和高烧入院。中国。直到医院第11天（疾病第21天），她才接受SARS-CoV-2RNA的测试，因为当地医院的测试试剂盒严重短缺。然后，在住院第20天，她的COVID-19检测呈阳性。尽管进行了密集的医疗治疗,患者出现呼吸衰竭,继发细菌感染,于住院第23天(SARS-CoV-2RNA检测阳性后3天)死亡.全身尸检检查,包括免疫组织化学和超微结构研究，证明SARS-CoV-2可以感染多个器官，对免疫系统产生深远的不利影响，肺部病理特征为弥漫性肺泡损伤。在死后的几个器官中检测到肺外SARS-CoV-2RNA。描述了详细的病理特征。此外,本报告强调了法医尸检在研究SARS-CoV-2感染方面的价值,以及临床病理相关性在更好地理解COVID-19发病机制方面的重要性.
