从 P 基因编码的辅助蛋白中筛选干扰素拮抗剂 , 用于山羊副流感病毒 3 的免疫逃逸。
关键词: Accessory protein Caprine parainfluenza virus 3 Interferon antagonist JAK/STAT signaling STAT1
Mesh : ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics Animals Antibodies, Monoclonal / pharmacology Antiviral Agents / pharmacology Cell Line Epithelial Cells / drug effects virology Female Goat Diseases / virology Goats / virology HEK293 Cells High-Throughput Screening Assays Humans Immune Evasion Interferon Type I / antagonists & inhibitors Interferon-alpha / pharmacology Mice Mice, Inbred BALB C Parainfluenza Virus 3, Human / drug effects genetics immunology Paramyxoviridae Infections / drug therapy veterinary Phosphorylation STAT1 Transcription Factor / antagonists & inhibitors genetics Signal Transduction / drug effects
来 源:
DOI:10.1016/j.vetmic.2021.108980
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