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Abstract：
BACKGROUND: This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).
METHODS: Systematic literature searches of PubMed, Embase, and EuropePMC databases were performed on 16 November 2020. Left ventricular global longitudinal strain (LV-GLS) refers to LV contraction measurement using the speckle tracking-based method refers to the mean of strain values of the RV free wall (three segments) measured using echocardiography. The main outcome was poor outcome, defined as a composite of mortality and severe COVID-19.
RESULTS: Seven studies comprising of 612 patients were included in meta-analysis. Six studies have mortality as their outcome, and 1 study has severity as their outcome. Patients with poor outcome have lower LV-GLS (SMD 1.15 (0.57, 1.72), p < 0.001; I2 70.4%). Each 1% decrease in LV-GLS was associated with 1.4x increased risk of poor outcome (OR 1.37 (1.12, 1.67), p = 0.002; I2 48.8%). Patients with poor outcome have lower RV-LS (SMD 1.18 (0.91, 1.45), p < 0.001; I2 0%). Each 1% decrease in RV-LS was associated with 1.3x increased risk of poor outcome (OR 1.25 (1.15, 1.35), p < 0.001; I2 11.8%). Subgroup analysis showed that for every 1% decrease in LV-GLS and RV-LS is increased mortality with OR of 1.30 (1.12, 1.50) and OR of 1.24 (1.14, 1.35), respectively.
CONCLUSIONS: This study shows that lower LV-GLS and RV-LS measurements were associated with poor outcome in patients with COVID-19.
BACKGROUND: PROSPERO CRD42020221144.
METHODS: Systematic literature searches of PubMed, Embase, and EuropePMC databases were performed on 16 November 2020. Left ventricular global longitudinal strain (LV-GLS) refers to LV contraction measurement using the speckle tracking-based method refers to the mean of strain values of the RV free wall (three segments) measured using echocardiography. The main outcome was poor outcome, defined as a composite of mortality and severe COVID-19.
RESULTS: Seven studies comprising of 612 patients were included in meta-analysis. Six studies have mortality as their outcome, and 1 study has severity as their outcome. Patients with poor outcome have lower LV-GLS (SMD 1.15 (0.57, 1.72), p < 0.001; I2 70.4%). Each 1% decrease in LV-GLS was associated with 1.4x increased risk of poor outcome (OR 1.37 (1.12, 1.67), p = 0.002; I2 48.8%). Patients with poor outcome have lower RV-LS (SMD 1.18 (0.91, 1.45), p < 0.001; I2 0%). Each 1% decrease in RV-LS was associated with 1.3x increased risk of poor outcome (OR 1.25 (1.15, 1.35), p < 0.001; I2 11.8%). Subgroup analysis showed that for every 1% decrease in LV-GLS and RV-LS is increased mortality with OR of 1.30 (1.12, 1.50) and OR of 1.24 (1.14, 1.35), respectively.
CONCLUSIONS: This study shows that lower LV-GLS and RV-LS measurements were associated with poor outcome in patients with COVID-19.
BACKGROUND: PROSPERO CRD42020221144.
摘要：
背景：这项系统评价和荟萃分析旨在评估心室纵向应变是否可以用作2019年冠状病毒病（COVID-19）患者的预测工具。
方法：PubMed的系统文献检索，Embase,和EuropePMC数据库于2020年11月16日进行。左心室整体纵向应变(LV-GLS)是指使用基于斑点追踪的方法测量的LV收缩是指使用超声心动图测量的RV游离壁(三个节段)的应变值的平均值。主要结果是结果不佳，定义为死亡率和严重COVID-19的复合。
结果：在荟萃分析中纳入了由612名患者组成的7项研究。六项研究的结果是死亡率，1项研究的结果是严重程度。预后不良的患者LV-GLS较低（SMD1.15（0.57，1.72），p<0.001；I270.4%）。LV-GLS每降低1%，不良结局风险增加1.4倍（OR1.37（1.12，1.67），p=0.002；I248.8%）。预后不良的患者RV-LS较低（SMD1.18（0.91，1.45），p<0.001；I20%)。RV-LS每减少1％，不良结局风险增加1.3倍（OR1.25（1.15，1.35），p<0.001；I211.8%）。亚组分析显示，LV-GLS和RV-LS每降低1%，死亡率增加，OR为1.30(1.12,1.50)，OR为1.24(1.14,1.35)，分别。
结论：这项研究表明，在COVID-19患者中，较低的LV-GLS和RV-LS测量值与不良预后相关。
背景：PROSPEROCRD42020221144.
方法：PubMed的系统文献检索，Embase,和EuropePMC数据库于2020年11月16日进行。左心室整体纵向应变(LV-GLS)是指使用基于斑点追踪的方法测量的LV收缩是指使用超声心动图测量的RV游离壁(三个节段)的应变值的平均值。主要结果是结果不佳，定义为死亡率和严重COVID-19的复合。
结果：在荟萃分析中纳入了由612名患者组成的7项研究。六项研究的结果是死亡率，1项研究的结果是严重程度。预后不良的患者LV-GLS较低（SMD1.15（0.57，1.72），p<0.001；I270.4%）。LV-GLS每降低1%，不良结局风险增加1.4倍（OR1.37（1.12，1.67），p=0.002；I248.8%）。预后不良的患者RV-LS较低（SMD1.18（0.91，1.45），p<0.001；I20%)。RV-LS每减少1％，不良结局风险增加1.3倍（OR1.25（1.15，1.35），p<0.001；I211.8%）。亚组分析显示，LV-GLS和RV-LS每降低1%，死亡率增加，OR为1.30(1.12,1.50)，OR为1.24(1.14,1.35)，分别。
结论：这项研究表明，在COVID-19患者中，较低的LV-GLS和RV-LS测量值与不良预后相关。
背景：PROSPEROCRD42020221144.
