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Abstract：
OBJECTIVE: Fumaric acid esters (FAEs) have been used for fifty years to treat moderate-to-severe psoriasis. However, recent case reports of progressive multifocal leukoencephalopathy, associated with FAE-induced lymphopaenia, have been a cause for concern (J Dtsch Dermatol Ges. 2009;7:603).
METHODS: We report six cases of persistent lymphopaenia following cessation of treatment with FAEs, with a mean duration of lymphopaenia of 33 months.
CONCLUSIONS: Given the lack of evidence regarding expected recovery of lymphocyte counts, further research is required to guide physicians in the risk stratification of patients prior to considering treatment with FAEs.
METHODS: We report six cases of persistent lymphopaenia following cessation of treatment with FAEs, with a mean duration of lymphopaenia of 33 months.
CONCLUSIONS: Given the lack of evidence regarding expected recovery of lymphocyte counts, further research is required to guide physicians in the risk stratification of patients prior to considering treatment with FAEs.
摘要：
目的：富马酸酯（FAE）已用于治疗中度至重度银屑病50年。然而,最近的多灶性白质脑病病例报告，与FAE诱导的淋巴细胞减少症相关，引起了人们的关注(JDtschDermatolGes。2009；7:603)。
方法：我们报告了6例FAE治疗停止后持续性淋巴细胞减少症，淋巴细胞减少症的平均持续时间为33个月。
结论：鉴于缺乏关于淋巴细胞计数预期恢复的证据，在考虑使用FAE治疗之前,需要进一步的研究来指导医师对患者进行风险分层.
方法：我们报告了6例FAE治疗停止后持续性淋巴细胞减少症，淋巴细胞减少症的平均持续时间为33个月。
结论：鉴于缺乏关于淋巴细胞计数预期恢复的证据，在考虑使用FAE治疗之前,需要进一步的研究来指导医师对患者进行风险分层.
