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Abstract：
Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient\'s quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach for VHD management is to replace or repair the injured valvular tissue with natural or synthetic biomaterials. Application of these biomaterials for cardiac valve regeneration and repair holds a great promise for treatment of this type of heart disease. The focus of the present review is the current use of different types of biomaterials in treatment of valvular heart diseases.
摘要：
瓣膜性心脏病（VHD）是由于瓣膜功能异常而发生的，这会大大降低患者的生活质量，如果不及时治疗可能导致死亡。不同的治疗方案可用于管理这种缺陷，这有助于减轻症状。降低VHD相关死亡率的全球承诺增加了对新治疗方法的需求。在过去的十年里，创新的药理学和手术方法的发展显着改善了VHD患者的生活质量，然而，寻找低成本，更有效,侵入性较小的方法正在进行中。VHD管理的金标准方法是用天然或合成生物材料替换或修复受损的瓣膜组织。这些用于心脏瓣膜再生和修复的生物材料的应用对于治疗这种类型的心脏病具有很大的希望。本综述的重点是当前不同类型的生物材料在心脏瓣膜病治疗中的应用。
