METHODS: All animal studies concerning hernia repair with meshes were systematically searched. Articles published in the 5 years leading up to the ARRIVE-2010 (pre-ARRIVE) and articles within the last 5 years until the updated ARRIVE 2.0 (post-ARRIVE) were compared for overall species and specific species separately. Articles published last year were evaluated for presenting fully reported (sub)items.
RESULTS: The number of fully reported (sub)items per article was on average significantly higher for pre-ARRIVE than post-ARRIVE for overall species (mean (SD) = 14.0 (2.8) vs. 12.6 (2.5), P < 0.001). The same applies to rabbit (mean (SD) = 14.8 (2.6) vs. 12.6 (2.6), P = 0.001) and pig studies (mean (SD) = 14.5 (2.7) vs. 11.6 (2.6), P = 0.004), with no significance in rat studies (mean (SD) = 13.6 (2.9) vs. 12.9 (2.3), P = 0.076). Significance was found in several (sub)items between pre-ARRIVE and post-ARRIVE (n = 7, 3, 8, and 3 for overall species, rat, rabbit, and pig studies, respectively).
CONCLUSIONS: General reporting quality of animal experiments has been improved markedly by ARRIVE guidelines. However, more improvements are required considering the arrival of ARRIVE 2.0 guidelines.
方法:系统搜索了所有关于疝修补术的动物研究。在ARRIVE-2010(ARRIVE前)之前的5年中发表的文章和在过去5年中直到更新的ARRIVE2.0(ARRIVE后)的文章分别针对总体物种和特定物种进行了比较。对去年发表的文章进行了评估,以介绍完全报告的(分)项目。
结果:ARRIVE前每篇文章的完整报告(子)项目数平均显着高于所有物种的ARRIVE后(平均值(SD)=14.0(2.8)与12.6(2.5),P<0.001)。这同样适用于兔子(平均值(SD)=14.8(2.6)与12.6(2.6),P=0.001)和猪研究(平均值(SD)=14.5(2.7)与11.6(2.6),P=0.004),在大鼠研究中没有显著性(平均值(SD)=13.6(2.9)与12.9(2.3),P=0.076)。在ARRIVE前和ARRIVE后的几个(子)项目中发现了意义(对于整个物种,n=7、3、8和3,rat,兔子,和猪研究,分别)。
结论:ARRIVE指南显著提高了动物实验的一般报告质量。然而,考虑到ARRIVE2.0指南的到来,还需要进行更多的改进。