PDF(Sci-hub)
Abstract：
The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature\'s medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant.
摘要：
目前已知氧化应激对健康的负面影响。自由基的复杂机制引发一系列连锁反应，这些连锁反应有助于不同退行性疾病的演变或发展。同样，这些疾病通常伴有炎症过程，因此,疼痛。在这个意义上,活性氧（ROS）已被证明可以促进伤害性过程，但是有效治疗疼痛和炎症仍然是一个挑战。随着时间的推移,据了解，没有单一的方法可以缓解疼痛，只要没有其他选择，趋势将继续应用多学科管理，例如促进传统使用刺桐属来管理疼痛和炎症。在这个意义上,刺桐属产生广泛的次生代谢产物,包括黄烷酮,异黄酮,异黄酮,和pterocarpans;这些化合物的特点是它们的抗氧化活性。酚类化合物已证明其抑制促氧化剂和抑制炎症信号通路如MAPK的能力，AP1和NFκB。尽管有临床前证据支持其使用，药理作用机制尚不完全清楚。如今,与药物发现相关的学科知识有了快速的进步，但是自然界的大部分药用潜力还没有被利用。这篇综述分析了刺桐属在控制由其化合物介导的炎性疼痛及其作为抗氧化剂的用途中可能发挥的决定性作用。
