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Abstract：
Acute lung injury is a serious form and major cause of patient death and still needs efficient therapies. The present study evidenced that co-transplantation of mesenchymal stem cells (MSCs) and telocytes (TCs) improved the severity of experimental lung tissue inflammation, edema, and injury, where TCs increased MSCs migration into the lung and the capacity of MSCs proliferation and movement. Of molecular mechanisms, Osteopontin-dominant networks were active in MSCs and TCs, and might play supportive and nutrimental roles in the interaction between MSCs and TCs, especially activated TCs by lipopolysaccharide. The interaction between epidermal growth factor and its receptor from MSCs and TCs could play critical roles in communications between MSCs and TCs, responsible for MSCs proliferation and movement, especially after inflammatory activation. Our studies provide the evidence that TCs possess nutrimental and supportive roles in implanted MSCs, and co-transplantation of MSCs and TCs can be a new alternative in the therapy of acute lung injury.
摘要：
急性肺损伤是患者死亡的严重形式和主要原因，仍然需要有效的治疗。本研究表明，间充质干细胞（MSCs）和端粒细胞（TCs）的共移植改善了实验性肺组织炎症的严重程度，水肿,和伤害,其中TC增加了MSCs迁移到肺中以及MSCs增殖和运动的能力。分子机制，骨桥蛋白显性网络在MSCs和TCs中是活跃的，并可能在MSCs和TC之间的相互作用中发挥支持和营养作用，特别是通过脂多糖激活的TC。表皮生长因子及其受体在MSCs与TCs之间的相互作用可能在MSCs与TCs之间的通讯中起关键作用,负责MSCs的增殖和运动，尤其是炎症激活后。我们的研究提供了证据，表明TC在植入的MSCs中具有营养和支持作用，MSCs和TCs联合移植可作为治疗急性肺损伤的新选择。
