PDF(Pubmed)
Abstract：
Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined. This study correlated human gastric slow wave velocity with ICC loss and aging. High-resolution gastric slow wave mapping data were screened from a database of 42 patients with severe gastric dysfunction (n = 20) and controls (n = 22). Correlations were performed between corpus slow wave conduction parameters (frequency, velocity, and amplitude) and corpus ICC counts in patients, and with age in controls. Physiological parameters were further integrated into computational models of gastric mixing. Patients: ICC count demonstrated a negative correlation with slow wave velocity in the corpus (i.e., higher velocities with reduced ICC; r2 = .55; p = .03). ICC count did not correlate with extracellular slow wave amplitude (p = .12) or frequency (p = .84). Aging: Age was positively correlated with slow wave velocity in the corpus (range: 25-74 years; r2 = .32; p = .02). Age did not correlate with extracellular slow wave amplitude (p = .40) or frequency (p = .34). Computational simulations demonstrated that the gastric emptying rate would increase at higher slow wave velocities. ICC loss and aging are associated with a higher slow wave velocity. The reason for these relationships is unexplained and merit further investigation. Increased slow wave velocity may modulate gastric emptying higher, although in gastroparesis other pathological factors must dominate to prevent emptying.
摘要：
Cajal间质细胞（ICC）的损失与胃功能障碍有关，在正常衰老期间也观察到，每十年减少约13％。ICC丢失对胃慢波传导速度的影响目前尚不明确。这项研究将人胃慢波速度与ICC丢失和衰老相关。从42例严重胃功能障碍患者（n=20）和对照组（n=22）的数据库中筛选了高分辨率胃慢波图数据。语料库慢波传导参数(频率，速度,和振幅)和患者的语料库ICC计数，控制年龄。将生理参数进一步整合到胃混合的计算模型中。患者：ICC计数与语料库中的慢波速度呈负相关(即，更高的速度和减少的ICC；r2=.55；p=.03)。ICC计数与细胞外慢波振幅（p=.12）或频率（p=.84）无关。年龄：年龄与语料库慢波速度呈正相关（范围：25-74岁；r2=.32；p=.02）。年龄与细胞外慢波振幅（p=0.40）或频率（p=0.34）无关。计算模拟表明，在较高的慢波速度下，胃排空率会增加。ICC损失和老化与较高的慢波速度相关。这些关系的原因是无法解释的，值得进一步调查。慢波速度增加可能会更高地调节胃排空，尽管在胃轻瘫中，其他病理因素必须占主导地位以防止排空。
