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Abstract：
Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to address historical clinical challenges in pulmonary diseases including multidrug resistance, adverse side effects of conventional therapeutic agents, novel imaging, and earlier disease detection. Nanomedicine is also being applied to tackle the new emerging infectious diseases, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), influenza A virus subtype H1N1 (A/H1N1), and more recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review we provide both a historical overview of the application of nanomedicine to respiratory diseases and more recent cutting-edge approaches such as nanoparticle-mediated combination therapies, novel double-targeted nondrug delivery system for targeting, stimuli-responsive nanoparticles, and theranostic imaging in the diagnosis and treatment of pulmonary diseases.
摘要：
纳米技术在医学-纳米医学-广泛用于诊断，请客,预防肺部疾病。在过去的几年里，这个勇敢的新世界取得了显著的进步，提供机会来解决肺部疾病的历史临床挑战，包括多药耐药性，常规治疗剂的不良副作用，新颖的成像，和早期的疾病检测。纳米医学也被用于应对新出现的传染病，包括严重急性呼吸道综合症冠状病毒（SARS-CoV），中东呼吸综合征冠状病毒（MERS-CoV）甲型流感病毒亚型H1N1(A/H1N1),最近，严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）。在这篇综述中，我们提供了纳米医学在呼吸系统疾病中的应用的历史概述，以及最新的尖端方法，如纳米颗粒介导的联合疗法。用于靶向的新型双靶向非药物递送系统，刺激响应性纳米粒子，在肺部疾病的诊断和治疗中的影像学。
