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Abstract：
UNASSIGNED: To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease (AERD) following endoscopic sinus surgery and subsequent aspirin desensitization.
UNASSIGNED: Electronic searches of OVID MEDLINE (1948 to September 10, 2019), EMBASE (1980 to September 10, 2019), and PubMed were performed on September 10, 2019. A systematic review of the literature was performed using the 2009 PRISMA guidelines. Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion. Publications were written in English and included patients aged 18 years or older.
UNASSIGNED: Six studies met inclusion criteria for this systematic review. The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores. The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery, with sustained improvement following aspirin desensitization. Revision surgery rates were significantly lower in patients maintained on aspirin therapy.
UNASSIGNED: This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures. The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores. Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is interrupted.
UNASSIGNED: Electronic searches of OVID MEDLINE (1948 to September 10, 2019), EMBASE (1980 to September 10, 2019), and PubMed were performed on September 10, 2019. A systematic review of the literature was performed using the 2009 PRISMA guidelines. Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion. Publications were written in English and included patients aged 18 years or older.
UNASSIGNED: Six studies met inclusion criteria for this systematic review. The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores. The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery, with sustained improvement following aspirin desensitization. Revision surgery rates were significantly lower in patients maintained on aspirin therapy.
UNASSIGNED: This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures. The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores. Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is interrupted.
摘要：
■回顾和评估内窥镜鼻窦手术和随后的阿司匹林脱敏后阿司匹林加重的呼吸系统疾病（AERD）患者的预后。
■OVIDMEDLINE的电子搜索（1948年至2019年9月10日），EMBASE(1980年至2019年9月10日),和PubMed于2019年9月10日进行。使用2009PRISMA指南对文献进行了系统回顾。对接受鼻窦手术和阿司匹林脱敏的AERD患者的术前和术后数据进行研究被认为是合适的。出版物用英语撰写，包括18岁或以上的患者。
■六项研究符合本系统评价的纳入标准。主要结局指标是通过患者报告的生活质量评分测量的症状变化。结果显示内窥镜鼻窦手术后症状有统计学意义的改善，阿司匹林脱敏后持续改善。接受阿司匹林治疗的患者的翻修手术率明显较低。
■本综述表明，手术后阿司匹林脱敏可改善主观和客观结果。阿司匹林脱敏的辅助使用允许症状评分的长期稳定性。当阿司匹林维持治疗中断时，息肉复发和需要进行翻修手术的症状恶化。
■OVIDMEDLINE的电子搜索（1948年至2019年9月10日），EMBASE(1980年至2019年9月10日),和PubMed于2019年9月10日进行。使用2009PRISMA指南对文献进行了系统回顾。对接受鼻窦手术和阿司匹林脱敏的AERD患者的术前和术后数据进行研究被认为是合适的。出版物用英语撰写，包括18岁或以上的患者。
■六项研究符合本系统评价的纳入标准。主要结局指标是通过患者报告的生活质量评分测量的症状变化。结果显示内窥镜鼻窦手术后症状有统计学意义的改善，阿司匹林脱敏后持续改善。接受阿司匹林治疗的患者的翻修手术率明显较低。
■本综述表明，手术后阿司匹林脱敏可改善主观和客观结果。阿司匹林脱敏的辅助使用允许症状评分的长期稳定性。当阿司匹林维持治疗中断时，息肉复发和需要进行翻修手术的症状恶化。
