METHODS: Subjects with Parkinson\'s disease were recruited. The following instruments were applied: Movement Disorders Society Unified Parkinson\'s Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment (MoCA), Toronto alexithymia scale (TAS-20) and Parkinson\'s Disease Questionnaire (PDQ-8). Matched healthy controls were screened using TAS-20. Clinical and demographical variables were compared between alexithymic and non-alexithymic. Regression models were used to find determinants of alexithymia. Impact of alexithymia on QoL was estimated with a linear regression model.
RESULTS: 98 patients were included. 56.1% PwP and 28.8% controls were alexithymic (p<0.001). Education level (OR 0.86) and NMSS urinary score (OR 1.09) determined alexithymia as well as TAS-20 score. Alexithymia was an independent determinant of QoL.
CONCLUSIONS: Alexithymia is a prevalent independent non-motor symptom in PwP with impact on QoL. Low education level and urinary symptoms are important determinants of alexithymia.
方法:招募帕金森病患者。应用了以下工具:运动障碍协会统一帕金森病评定量表(MDS-UPDRS),非运动症状量表(NMSS),蒙特利尔认知评估(MoCA)多伦多述情障碍量表(TAS-20)和帕金森病问卷(PDQ-8)。使用TAS-20筛选匹配的健康对照。临床和人口统计学变量在情胸腺和非情胸腺之间进行了比较。回归模型用于找到述情障碍的决定因素。用线性回归模型估计述情障碍对QoL的影响。
结果:98例患者被纳入。56.1%的PwP和28.8%的对照组为情胸腺(p<0.001)。教育水平(OR0.86)和NMSS尿评分(OR1.09)决定了述情障碍和TAS-20评分。述情障碍是QoL的独立决定因素。
结论:述情障碍是PwP中普遍存在的独立非运动症状,对QoL有影响。低教育水平和泌尿症状是述情障碍的重要决定因素。