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Abstract：
Pseudoxanthoma elasticum (PXE) is a systemic disease affecting the skin, eyes, and cardiovascular system of patients. Cardiovascular disease is associated with osteoarthritis (OA), which is the most common cause of joint pain. There is a lack of systematic investigations on joint manifestations in PXE in the literature. In this explorative study, we aimed to investigate whether patients with PXE are more at risk for developing osseous signs of OA. Patients with PXE and hospital controls with whole-body low-dose CT examinations available were included. OA was assessed using the OsteoArthritis Computed Tomography (OACT)-score, which is a 4-point Likert scale, in the acromioclavicular (AC), glenohumeral (GH), facet, hip, knee, and ankle joints. Additionally, intervertebral disc degeneration was scored. Data were analyzed using ordinal logistic regression adjusted for age, body mass index (BMI), and smoking status. In total, 106 PXE patients (age 56 (48-64), 42% males, BMI 25.3 (22.7-28.2)) and 87 hospital controls (age 55 (43-67), 46% males, BMI 26.0 (22.5-29.2)) were included. PXE patients were more likely to have a higher OA score for the AC joints (OR 2.00 (1.12-3.61)), tibiofemoral joint (OR 2.63 (1.40-5.07)), and patellofemoral joint (2.22 (1.18-4.24)). For the other joints, the prevalence and severity of OA did not differ significantly. This study suggests that patients with PXE are more likely to have structural OA of the knee and AC joints, which needs clinical confirmation in larger groups and further investigation into the mechanism.
摘要：
弹性假性黄瘤（PXE）是一种影响皮肤的全身性疾病，眼睛,和患者的心血管系统。心血管疾病与骨关节炎（OA）有关，这是关节疼痛最常见的原因。文献中缺乏对PXE联合表现的系统研究。在这项探索性研究中，我们的目的是调查PXE患者是否更容易出现骨性OA.包括PXE患者和可进行全身低剂量CT检查的医院对照。OA使用骨关节计算机断层扫描（OACT）评分进行评估，这是一个4分的李克特音阶，在肩锁（AC），肱骨(GH),facet,臀部,膝盖,和踝关节。此外,对椎间盘退变进行评分。数据采用序数逻辑回归分析，调整年龄，体重指数（BMI），和吸烟状况。总的来说,106名PXE患者（年龄56（48-64），42%的男性,BMI25.3（22.7-28.2））和87名医院控制（年龄55（43-67），46%的男性，包括BMI26.0（22.5-29.2）。PXE患者的AC关节OA评分更高（OR2.00（1.12-3.61）），胫股关节（OR2.63（1.40-5.07）），和髌股关节（2.22（1.18-4.24））。对于其他关节，OA的患病率和严重程度无显著差异.这项研究表明，患有PXE的患者更有可能患有膝关节和AC关节的结构性OA，这需要在更大的群体中进行临床确认，并进一步研究其机制。
