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Abstract：
For a population with knee osteoarthritis (OA), determine: 1) the prevalence of single compartmental, bicompartmental and tricompartmental OA, 2) the prevalence of isolated medial tibiofemoral, lateral tibiofemoral, or patellofemoral OA, and combinations thereof.
PubMed and Web of Science databases, and reference lists of identified studies, were searched to find studies which reported on the compartmental distribution and prevalence of knee OA. Two independent reviewers assessed studies against pre-defined inclusion criteria and prevalence data were extracted along with subject characteristics. The methodological quality of each included study was assessed. A random-effects model meta-analysis was performed for each OA category to estimate the relative prevalence of OA in the knee compartments amongst people with knee OA.
16 studies (3,786 knees) met the inclusion criteria. High heterogeneity was measured. Normalised for knees with OA, estimated prevalence rates (95% CI) were: single compartmental 50% (31.5-58.3%), bicompartmental 33% (23.1-37.2%) and tricompartmental only 17% (8.8-24.8%). Isolated medial tibiofemoral OA, isolated patellofemoral OA, and combined medial tibiofemoral and patellofemoral OA were more common than tricompartmental disease, occurring in 27% (15.2-31.1%), 18% (9.9-22.7%) and 23% (14.1-27.3%) of people respectively. Single/bicompartmental patterns of disease involving the lateral tibiofemoral compartment were less common, summing to 15% (8.5-18.7%).
Three-quarters of people with knee OA do not have tricompartmental disease. This is not reflected in the frequency with which partial and combined partial knee arthroplasties are currently used.
PROSPERO systematic review protocol (CRD42019140345).
PubMed and Web of Science databases, and reference lists of identified studies, were searched to find studies which reported on the compartmental distribution and prevalence of knee OA. Two independent reviewers assessed studies against pre-defined inclusion criteria and prevalence data were extracted along with subject characteristics. The methodological quality of each included study was assessed. A random-effects model meta-analysis was performed for each OA category to estimate the relative prevalence of OA in the knee compartments amongst people with knee OA.
16 studies (3,786 knees) met the inclusion criteria. High heterogeneity was measured. Normalised for knees with OA, estimated prevalence rates (95% CI) were: single compartmental 50% (31.5-58.3%), bicompartmental 33% (23.1-37.2%) and tricompartmental only 17% (8.8-24.8%). Isolated medial tibiofemoral OA, isolated patellofemoral OA, and combined medial tibiofemoral and patellofemoral OA were more common than tricompartmental disease, occurring in 27% (15.2-31.1%), 18% (9.9-22.7%) and 23% (14.1-27.3%) of people respectively. Single/bicompartmental patterns of disease involving the lateral tibiofemoral compartment were less common, summing to 15% (8.5-18.7%).
Three-quarters of people with knee OA do not have tricompartmental disease. This is not reflected in the frequency with which partial and combined partial knee arthroplasties are currently used.
PROSPERO systematic review protocol (CRD42019140345).
摘要：
对于患有膝骨关节炎（OA）的人群，确定：1)单室的患病率，双室和三室OA，2)孤立内侧胫骨股的患病率，胫骨外侧，或者髌股OA,及其组合。
PubMed和WebofScience数据库,以及已确定研究的参考清单，进行了搜索，以找到有关膝关节OA的隔室分布和患病率的研究。两名独立的审查人员根据预定义的纳入标准评估了研究，并提取了患病率数据以及受试者特征。评估每个纳入研究的方法学质量。对每个OA类别进行随机效应模型荟萃分析，以估计膝关节OA患者的膝关节隔室中OA的相对患病率。
16项研究（3,786膝）符合纳入标准。测量到高度异质性。OA的膝盖正常化，估计患病率（95%CI）为：单室50%（31.5-58.3%），双室33%(23.1-37.2%)和三室只有17%(8.8-24.8%)。孤立性内侧胫骨股OA，孤立性髌股OA，合并内侧胫骨和髌股OA比三室疾病更常见，发生在27%(15.2-31.1%)，分别占18％（9.9-22.7％）和23％（14.1-27.3％）。单/双房型累及胫股外侧隔室的疾病较少见，合计至15%（8.5-18.7%）。
四分之三的膝关节OA患者没有三室疾病。这没有反映在当前使用部分和组合部分膝关节置换术的频率上。
PROSPERO系统评价方案(CRD42019140345)。
PubMed和WebofScience数据库,以及已确定研究的参考清单，进行了搜索，以找到有关膝关节OA的隔室分布和患病率的研究。两名独立的审查人员根据预定义的纳入标准评估了研究，并提取了患病率数据以及受试者特征。评估每个纳入研究的方法学质量。对每个OA类别进行随机效应模型荟萃分析，以估计膝关节OA患者的膝关节隔室中OA的相对患病率。
16项研究（3,786膝）符合纳入标准。测量到高度异质性。OA的膝盖正常化，估计患病率（95%CI）为：单室50%（31.5-58.3%），双室33%(23.1-37.2%)和三室只有17%(8.8-24.8%)。孤立性内侧胫骨股OA，孤立性髌股OA，合并内侧胫骨和髌股OA比三室疾病更常见，发生在27%(15.2-31.1%)，分别占18％（9.9-22.7％）和23％（14.1-27.3％）。单/双房型累及胫股外侧隔室的疾病较少见，合计至15%（8.5-18.7%）。
四分之三的膝关节OA患者没有三室疾病。这没有反映在当前使用部分和组合部分膝关节置换术的频率上。
PROSPERO系统评价方案(CRD42019140345)。
