关键词: Cataract-causing mutation Protein aggregation Protein degradation βB2-crystallin
Mesh : Cataract / congenital drug therapy genetics pathology Child, Preschool DNA Mutational Analysis Female HEK293 Cells HeLa Cells Humans Hydrophobic and Hydrophilic Interactions / drug effects Lanosterol / pharmacology therapeutic use Lens, Crystalline / drug effects pathology Male Molecular Dynamics Simulation Mutagenesis, Site-Directed Mutation Pedigree Protein Aggregation, Pathological / congenital drug therapy genetics Protein Conformation, beta-Strand / drug effects genetics Proteolysis / drug effects Recombinant Proteins / chemistry genetics isolation & purification metabolism Trypsin / metabolism beta-Crystallin B Chain / chemistry genetics isolation & purification metabolism
来 源:
DOI:10.1016/j.bbadis.2020.166018
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