关键词： 3CLpro, 3C-like protease 6-HB, six-helix bundle ACE2, angiotensin-converting enzyme 2 COVID-19 COVID-19, coronavirus disease 2019 CatB/L, cysteine proteases-cathepsin B and L Drug-screening E protein, Envelope protein Genome-encoded proteins HR1, heptad repeat 1 HR2, heptad repeat 2 M protein, Membrane protein MERS-CoV, the Middle Eastern respiratory syndrome coronavirus Mpro, Main protease N protein, Nucleocapsid protein NSP, non-structural protein ORF, Open reading frame PD, peptidase domain RBD, receptor-binding domain RBM, receptor-binding motif RMP, The remdesivir monophosphate RdRp, RNA-dependent RNA polymerase S protein, Spike glycoprotein SARS-CoV, severe acute respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 Structure-based screening gRNA, genomic RNA sgRNA, subgenomic RNA

来  源：   DOI：10.1016/j.crmicr.2020.06.003   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization, broke out in China and rapidly developed into a global pandemic, with millions of cases and hundreds of thousands of deaths reported globally. The novel coronavirus, which was designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the etiological agent of COVID-19. On the basis of experience accumulated following previous SARS-CoV and MERS-CoV outbreaks and research, a series of studies have been conducted rapidly, and major progress has been achieved with regard to the understanding of the phylogeny and genomic organization of SARS-CoV-2 in addition its molecular mechanisms of infection and replication. In the present review, we summarized crucial developments in the elucidation of the structure and function of key SARS-CoV-2 proteins, especially the main protease, RNA-dependent RNA polymerase, spike glycoprotein, and nucleocapsid protein. Results of studies on their associated inhibitors and drugs have also been highlighted.
摘要：
一种严重的肺炎，被世界卫生组织命名为2019年冠状病毒病(COVID-19)，在中国爆发并迅速发展成为全球大流行，全球报告了数百万例病例和数十万例死亡病例。新型冠状病毒,被指定为严重急性呼吸道综合症冠状病毒2（SARS-CoV-2），被确定为COVID-19的病原体。根据以往SARS-CoV和MERS-CoV爆发和研究积累的经验，一系列研究迅速进行，在理解SARS-CoV-2的系统发育和基因组组织以及其感染和复制的分子机制方面取得了重大进展。在本次审查中，我们总结了在阐明SARS-CoV-2关键蛋白的结构和功能方面的重要进展，尤其是主要的蛋白酶，RNA依赖性RNA聚合酶，刺突糖蛋白，和核衣壳蛋白。有关其相关抑制剂和药物的研究结果也得到了强调。
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