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Abstract：
OBJECTIVE: To describe the clinical characteristics and risk factors associated with the progression of COVID-19 in elderly diabetes patients.
METHODS: This was a retrospective cohort study, including elderly COVID-19 patients admitted to Wuhan Huoshenshan Hospital between February 10 and 13, 2020. Demographic data, medical history, signs and symptoms, and laboratory parameters were collected and analysed.
RESULTS: We included 131 elderly COVID-19 patients (50 patients with diabetes). COVID-19 diabetes patients experienced more severe pneumonia and abnormal organ functions than non-diabetes patients (P < 0.05 or P < 0.01). Most function indicators were significantly different between the mild to moderate and severely ill groups in diabetes patients (P < 0.05 or P < 0.01). Python analysis confirmed diabetes was the independent risk factor of COVID-19 progression in elderly patients. All blood glucose (BG) indices went into the risk factor equation. The cut-off values of COVID-19 progression were BG value on admission > 8.0 mmol/L or maximum BG value > 12.0 mmol/L in all elderly patients, and BG value on admission > 5.1 mmol/L or maximum BG value > 5.4 mmol/L in non-diabetes patients.
CONCLUSIONS: Diabetes is an independent important risk factor, and glucose levels associate closely with COVID-19 progression in elderly patients.
METHODS: This was a retrospective cohort study, including elderly COVID-19 patients admitted to Wuhan Huoshenshan Hospital between February 10 and 13, 2020. Demographic data, medical history, signs and symptoms, and laboratory parameters were collected and analysed.
RESULTS: We included 131 elderly COVID-19 patients (50 patients with diabetes). COVID-19 diabetes patients experienced more severe pneumonia and abnormal organ functions than non-diabetes patients (P < 0.05 or P < 0.01). Most function indicators were significantly different between the mild to moderate and severely ill groups in diabetes patients (P < 0.05 or P < 0.01). Python analysis confirmed diabetes was the independent risk factor of COVID-19 progression in elderly patients. All blood glucose (BG) indices went into the risk factor equation. The cut-off values of COVID-19 progression were BG value on admission > 8.0 mmol/L or maximum BG value > 12.0 mmol/L in all elderly patients, and BG value on admission > 5.1 mmol/L or maximum BG value > 5.4 mmol/L in non-diabetes patients.
CONCLUSIONS: Diabetes is an independent important risk factor, and glucose levels associate closely with COVID-19 progression in elderly patients.
摘要：
目的：描述老年糖尿病患者COVID-19进展的临床特征和危险因素。
方法：这是一项回顾性队列研究，包括2020年2月10日至13日入住武汉霍神山医院的老年COVID-19患者。人口统计数据,病史,症状和体征,和实验室参数进行了收集和分析。
结果：我们纳入了131例老年COVID-19患者（50例糖尿病患者）。COVID-19糖尿病患者出现严重肺炎和脏器功能异常的患者多于非糖尿病患者(P<0.05或P<0.01)。糖尿病患者轻、中、重度组的各项功能指标差异有统计学意义(P<0.05或P<0.01)。Python分析证实糖尿病是老年患者COVID-19进展的独立危险因素。所有血糖（BG）指标均进入危险因素方程。所有老年患者COVID-19进展的临界值为入院时BG值>8.0mmol/L或最大BG值>12.0mmol/L，非糖尿病患者入院时的BG值>5.1mmol/L或最大BG值>5.4mmol/L。
结论：糖尿病是独立的重要危险因素，血糖水平与老年患者COVID-19进展密切相关。
方法：这是一项回顾性队列研究，包括2020年2月10日至13日入住武汉霍神山医院的老年COVID-19患者。人口统计数据,病史,症状和体征,和实验室参数进行了收集和分析。
结果：我们纳入了131例老年COVID-19患者（50例糖尿病患者）。COVID-19糖尿病患者出现严重肺炎和脏器功能异常的患者多于非糖尿病患者(P<0.05或P<0.01)。糖尿病患者轻、中、重度组的各项功能指标差异有统计学意义(P<0.05或P<0.01)。Python分析证实糖尿病是老年患者COVID-19进展的独立危险因素。所有血糖（BG）指标均进入危险因素方程。所有老年患者COVID-19进展的临界值为入院时BG值>8.0mmol/L或最大BG值>12.0mmol/L，非糖尿病患者入院时的BG值>5.1mmol/L或最大BG值>5.4mmol/L。
结论：糖尿病是独立的重要危险因素，血糖水平与老年患者COVID-19进展密切相关。
