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Abstract：
During signal transduction, multivalent interactions establish dynamic molecular connectivities that propagate molecular cascades throughout the entire signaling pathway. Such multivalent interactions include the initial activation, cascade signal transduction, and the amplification and assembly of structural machinery. For example, plants rapidly remodel the actin cytoskeleton during signal transduction by perceiving a wide range of mechanical and chemical cues from developmental and defense pathways. Actin treadmilling is stepwise-regulated by interactions between actin and actin-binding proteins (ABPs). Emerging evidence shows that intrinsically disordered regions (IDRs) enable flexible and promiscuous interactions that serve as the functional hub for generating cellular interactomes underlying various signaling events. Though IDRs are present in a majority of ABPs, few of the functional roles of IDR in the interaction and functions of ABPs have been defined. The distinct features of IDRs create diverse and dynamic molecular interactions that introduce a new paradigm to our understanding of the structure-function relationships for actin assembly. In this review, we will create a snapshot of recent advances in IDR-mediated plant actin remodeling and discuss future research directions in studying the complexity of actin assembly via multifaceted biomolecular assembly during signal transduction.
摘要：
在信号转导过程中，多价相互作用建立了动态的分子连接，在整个信号传导途径中传播分子级联。这种多价相互作用包括初始激活，级联信号转导，以及结构机械的放大和组装。例如,植物通过感知发育和防御途径的各种机械和化学线索，在信号转导过程中迅速重塑肌动蛋白细胞骨架。肌动蛋白四磨是通过肌动蛋白和肌动蛋白结合蛋白（ABP）之间的相互作用逐步调节的。新出现的证据表明，内在无序区域（IDR）能够实现灵活和混杂的相互作用，这些相互作用充当了生成各种信号事件背后的细胞相互作用的功能枢纽。尽管IDR存在于大多数ABP中，已经定义了IDR在ABPs相互作用和功能中的功能作用。IDR的独特特征创造了多样化和动态的分子相互作用，为我们对肌动蛋白组装的结构-功能关系的理解引入了新的范式。在这次审查中,我们将创建最近的进展在IDR介导的植物肌动蛋白重塑的快照，并讨论未来的研究方向，研究复杂的肌动蛋白组装通过多方面的生物分子组装在信号转导过程中。
