Abstract:
Protein kinase A (PKA) is an important intracellular substance that regulates substance metabolism and biological functions, which exerts a wide range of biological effects through phosphorylation of specific serine/threonine residues in specific proteins. PKA plays an important role in the cAMP signaling pathway, and is involved in various life activities of parasites. Therefore, investigating the role of PKA in the life activities of parasites may provide insights into the development of novel anti-parasitic targets. The review mainly describes the structure and function of PKA and its role in life activities of parasites.
[摘要] 蛋白激酶A (Protein kinase A, PKA) 是细胞内具有调节物质代谢和生物学功能的重要物质, 通过对特定蛋白质 丝/苏氨酸残基磷酸化来发挥一系列生物学效应, 在 cAMP 信号通路中扮演着重要作用。 PKA 也参与寄生虫的各项生命 活动, 研究 PKA 在寄生虫生命活动中发挥的作用可以为研发新的抗寄生虫药物靶点提供线索。本文主要就 PKA 的结构、功能及其在寄生虫生命活动中的作用研究进展作一综述。.