PDF(Pubmed)
Abstract：
Mouse Mex3c encodes RNA-binding proteins of variant length through alternative splicing. Its mutation results in multiple defects including growth retardation, perturbed energy balance, and defective antiviral innate immunity. Here we report that Mex3c mutation affects mammary gland development and lactation in female mice. Pups of Mex3c mutant dams die of starvation soon after birth. Milk contents are present in the alveoli but deficient in the ducts of the mammary glands in mutant mice. Mutant mice do not show prolactin or oxytocin deficiency. They also develop myoepithelial cells in the mammary glands. Mex3c is expressed in the mammary gland epithelium. Our data suggest that functional defects in mammary gland epithelium or myoepithelial cells could cause lactation defects.
摘要：
小鼠Mex3c通过可变剪接编码变异长度的RNA结合蛋白。它的突变导致多种缺陷，包括生长迟缓，扰动的能量平衡，和抗病毒先天免疫缺陷。在这里，我们报道了Mex3c突变会影响雌性小鼠的乳腺发育和泌乳。Mex3c突变水坝的幼崽在出生后不久就死于饥饿。在突变小鼠中，牛奶含量存在于肺泡中，但在乳腺导管中缺乏。突变小鼠不显示催乳素或催产素缺乏。它们还在乳腺中发育肌上皮细胞。Mex3c在乳腺上皮中表达。我们的数据表明，乳腺上皮或肌上皮细胞的功能缺陷可能导致泌乳缺陷。
