METHODS: A total of 5 doses of 10 μg of hepatitis B vaccine was given intradermally, 2 weeks apart, to both the study groups: patients who were on hemodialysis and the general population group who previously had failed to achieve satisfactory antibody titers with the IM administration of the vaccine. A hepatitis B surface antibody (HBsAb) titer of ≥10 IU/mL and ≥100 IU/mL were considered \"responder\" and \"good responder,\" respectively.
RESULTS: Out of a total of 95 participants, 49 (51.6%) were hemodialysis-dependent. Most of the participants were females 49 (51.6%). The mean age of all the participants was 39.02 ± 13.5 years (range: 18-70 years). Overall, 75.8% of the participants responded to the ID vaccination with a mean HBsAb titer of 263.5 ± 350.1 IU/L. Almost similar vaccination response was observed in both the hemodialysis and general population i.e., 75.5% and 76.1%, respectively (P = 1.00). In the hemodialysis group, the absence of hypertension (P = 0.04) and age ≥36 years (P = 0.016) were associated with an ID vaccination response.
CONCLUSIONS: For those not responding to the conventional IM route of the hepatitis B vaccine, the ID route is an effective way of immunization in this group and this approach would lead to a decrease in infection rates in the vulnerable population such as those on hemodialysis.
方法:皮内给予共5剂10μg乙肝疫苗,相隔两周,这两个研究组:接受血液透析的患者和以前通过IM接种疫苗未能达到令人满意的抗体滴度的普通人群组.乙肝表面抗体(HBsAb)滴度≥10IU/mL和≥100IU/mL被认为是“应答者”和“良好应答者,\"分别。
结果:在总共95名参与者中,49(51.6%)是血液透析依赖性。大多数参与者是女性49(51.6%)。所有参与者的平均年龄为39.02±13.5岁(范围:18-70岁)。总的来说,75.8%的参与者对ID疫苗接种有反应,平均HBsAb滴度为263.5±350.1IU/L。在血液透析和普通人群中观察到几乎相似的疫苗接种反应,即75.5%和76.1%,分别(P=1.00)。在血液透析组,无高血压(P=0.04)和年龄≥36岁(P=0.016)与ID疫苗接种应答相关.
结论:对于那些对乙肝疫苗的常规IM途径没有反应的人,在该组中,ID途径是一种有效的免疫方法,这种方法将导致脆弱人群如血液透析人群的感染率降低.