Abstract:
Cranberry powder (CR) is reported to be effective against lower urinary tract symptoms (LUTS) and recurrent urinary tract infections. Benign prostatic hyperplasia (BPH) in men older than 50 years is a common cause of LUTS. Here, we attempted to evaluate if CR is also effective for treating BPH using a BPH-induced rat model, which was orally administered CR. Male Sprague-Dawley rats weighing 200-250 g were randomly divided into the following six groups (n = 9): noncastration group; castration group; BPH group; BPH and cranberry for 8-week (CR8W) group; BPH and cranberry for 4-week (CR4W) group; and BPH and saw palmetto group (saw palmetto). Compared with the BPH group, the CR8W group showed a significant decrease in prostate weight (by 33%), dihydrotestosterone (DHT) levels (by 18% in serum and 28% in prostate), 5-alpha reductase levels (18% reduction of type 1 and 35% of type 2), and histological changes. These results indicate that CR could attenuate BPH by inhibiting 5-alpha reductase and by reducing other biomarkers such as prostate weight and DHT levels. Thus, CR may be an effective candidate for the development of a functional food for BPH treatment. IACUC (USW-IACUC-R-2015-004).
摘要:
据报道,蔓越莓粉(CR)可有效对抗下尿路症状(LUTS)和复发性尿路感染。50岁以上男性的良性前列腺增生(BPH)是LUTS的常见原因。这里,我们尝试使用BPH诱导的大鼠模型评估CR是否也对治疗BPH有效,口服CR。体重200-250g的雄性Sprague-Dawley大鼠随机分为以下6组(n=9):非去势组;去势组;BPH和蔓越莓8周(CR8W)组;BPH和蔓越莓4周(CR4W)组;BPH和锯棕榈组(锯棕榈)。与BPH组相比,CR8W组显示前列腺重量显著下降(33%),双氢睾酮(DHT)水平(血清中18%,前列腺中28%),5-α还原酶水平(1型减少18%,2型减少35%),和组织学变化。这些结果表明CR可以通过抑制5-α还原酶和通过降低其他生物标志物如前列腺重量和DHT水平来减弱BPH。因此,CR可能是开发用于BPH治疗的功能性食品的有效候选物。IACUC(USW-IACUC-R-2015-004)。