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Abstract：
Cranberry powder (CR) is reported to be effective against lower urinary tract symptoms (LUTS) and recurrent urinary tract infections. Benign prostatic hyperplasia (BPH) in men older than 50 years is a common cause of LUTS. Here, we attempted to evaluate if CR is also effective for treating BPH using a BPH-induced rat model, which was orally administered CR. Male Sprague-Dawley rats weighing 200-250 g were randomly divided into the following six groups (n = 9): noncastration group; castration group; BPH group; BPH and cranberry for 8-week (CR8W) group; BPH and cranberry for 4-week (CR4W) group; and BPH and saw palmetto group (saw palmetto). Compared with the BPH group, the CR8W group showed a significant decrease in prostate weight (by 33%), dihydrotestosterone (DHT) levels (by 18% in serum and 28% in prostate), 5-alpha reductase levels (18% reduction of type 1 and 35% of type 2), and histological changes. These results indicate that CR could attenuate BPH by inhibiting 5-alpha reductase and by reducing other biomarkers such as prostate weight and DHT levels. Thus, CR may be an effective candidate for the development of a functional food for BPH treatment. IACUC (USW-IACUC-R-2015-004).
摘要：
据报道，蔓越莓粉（CR）可有效对抗下尿路症状（LUTS）和复发性尿路感染。50岁以上男性的良性前列腺增生（BPH）是LUTS的常见原因。这里,我们尝试使用BPH诱导的大鼠模型评估CR是否也对治疗BPH有效,口服CR。体重200-250g的雄性Sprague-Dawley大鼠随机分为以下6组（n=9）：非去势组；去势组；BPH和蔓越莓8周（CR8W）组；BPH和蔓越莓4周（CR4W）组；BPH和锯棕榈组（锯棕榈）。与BPH组相比，CR8W组显示前列腺重量显著下降（33%），双氢睾酮（DHT）水平（血清中18％，前列腺中28％），5-α还原酶水平（1型减少18％，2型减少35％），和组织学变化。这些结果表明CR可以通过抑制5-α还原酶和通过降低其他生物标志物如前列腺重量和DHT水平来减弱BPH。因此，CR可能是开发用于BPH治疗的功能性食品的有效候选物。IACUC（USW-IACUC-R-2015-004）。
