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Abstract：
Polychlorinated biphenyls (PCBs) are a typical class of environmental contaminants recently shown to be metabolism-disrupting chemicals. Lipids are a highly complex group of biomolecules that not only form the structural basis of biofilms but also act as signaling molecules and energy sources. Lipid metabolic disorders contribute to multiple diseases, including obesity, diabetes, fatty liver, and metabolic syndromes. Although previous literature has reported that PCBs can affect lipid metabolism, including lipid synthesis, uptake, and elimination, few systematic summaries of the detailed process of lipid metabolism caused by PCB exposure have been published. Lipid metabolic processes involve many molecules; however, the key factors that are sensitive to PCB exposure have not been fully clarified. Here, we summarize the recent developments in PCB research with a focus on biomarkers of lipid metabolic disorders related to environmental exposures.
摘要：
多氯联苯（PCBs）是一类典型的环境污染物，最近被证明是破坏代谢的化学物质。脂质是一组高度复杂的生物分子，不仅形成生物膜的结构基础，而且还充当信号分子和能源。脂质代谢紊乱导致多种疾病，包括肥胖,糖尿病,脂肪肝,和代谢综合征。尽管以前的文献报道多氯联苯可以影响脂质代谢，包括脂质合成，摄取，消除,关于PCB暴露引起的脂质代谢的详细过程的系统总结很少。脂质代谢过程涉及许多分子;然而，对PCB暴露敏感的关键因素尚未完全阐明。这里,我们总结了PCB研究的最新进展，重点是与环境暴露相关的脂质代谢紊乱的生物标志物。
