SARM1 耗竭挽救 NMNAT1 依赖性感光细胞死亡和视网膜变性。
关键词: LCA9 NAD+ NMNAT1 SARM1 axonal degeneration mouse neuroscience retinal degenerations
Mesh : Animals Armadillo Domain Proteins / genetics metabolism Cell Death Cytoskeletal Proteins / genetics metabolism Disease Models, Animal Female Humans Leber Congenital Amaurosis / genetics pathology Male Mice Nicotinamide-Nucleotide Adenylyltransferase / genetics metabolism Photoreceptor Cells, Vertebrate / pathology Retinal Degeneration / genetics pathology
来 源:
DOI:10.7554/eLife.62027
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