PDF(Sci-hub)
Abstract：
Derma roller, a device rolled onto the skin to form micropores, is extensively used for cosmetic purposes. The pores thus created are utilized to either result in the induction of collagen production, leading to glowing and wrinkle-free skin or for permeating the applied formulations to the site of action within the skin. Recent studies have shown the benefits of using derma rollers for transdermal delivery of drugs. In the nascent stage, this approach paves a way to successfully breach the stratum corneum and aid in the movement of medications directed towards the dermis and the hair follicles. The review essentially summarizes the evidence of the use of derma rollers in cosmetic setup, their designing, and the preclinical and clinical reports of efficacy, safety, and concerns when translated for pharmaceutical purposes and transdermal drug delivery.
摘要：
皮肤辊,滚动到皮肤上形成微孔的装置，广泛用于化妆品目的。这样产生的孔被用来诱导胶原蛋白的产生，导致皮肤发光和无皱纹或使所施用的制剂渗透至皮肤内的作用部位。最近的研究已经显示了使用皮肤辊经皮递送药物的益处。在新生阶段，这种方法为成功破坏角质层和帮助药物朝向真皮和毛囊的运动铺平了道路。这篇综述基本上总结了在化妆品设置中使用真皮辊的证据，他们的设计，以及疗效的临床前和临床报告，安全,和关注当翻译为药物目的和经皮药物递送。
