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Abstract：
Residue chemists who analyse pesticides in vegetables or veterinary drugs in animal-based food are currently facing a situation where there is a requirement to detect more and more compounds at lower and lower concentrations. Conventional tandem quadrupole instruments provide sufficient sensitivity, but speed and selectivity appear as future limitations. This will become an even larger issue when there is a need to not only detect active compounds but also their degradation products and metabolites. This will likely lead to a situation in which the conventional targeted approach must be expanded or augmented by a certain non-targeted strategy. High-resolution mass spectrometry provides such capabilities, but it frequently requires an additional degree of selectivity for the unequivocal confirmation of analytes present at trace levels in highly complex and variable food matrices. The hyphenation of ultrahigh performance liquid chromatography with ion mobility and high-resolution mass spectrometry provides analytical chemists with a new tool for performing such a demanding multiresidue analysis. The objective of this paper is to investigate the benefits of the added ion mobility dimension as well as to critically discuss the current limitations of this commercially available technology.
摘要：
分析蔬菜中的农药或动物性食品中的兽药的残留化学家目前面临着这样的情况，即需要在越来越低的浓度下检测越来越多的化合物。传统的串联四极杆仪器提供足够的灵敏度，但是速度和选择性似乎是未来的限制。当不仅需要检测活性化合物而且需要检测它们的降解产物和代谢物时,这将成为更大的问题。这可能会导致一种情况，即必须通过某种非目标战略来扩大或增强传统的目标方法。高分辨率质谱提供了这样的能力，但它通常需要额外的选择性，以明确确认高度复杂和可变的食物基质中痕量存在的分析物。超高效液相色谱与离子迁移和高分辨率质谱的连字符为分析化学家提供了一种新工具，用于执行如此苛刻的多残基分析。本文的目的是研究增加离子迁移率维度的好处，并批判性地讨论这种市售技术的当前局限性。
