关键词: Antiproliferative Apoptosis Non Hodgkin's lymphoma PI3Kδ inhibitor Piperazinone Purine
Mesh : Animals Antineoplastic Agents / chemical synthesis pharmacology Cell Line, Tumor Cell Proliferation / drug effects Drug Design Enzyme Inhibitors / chemical synthesis pharmacology Heterografts Humans Lymphoma, Non-Hodgkin / drug therapy Mice, SCID Mitogen-Activated Protein Kinase Kinases / metabolism Molecular Docking Simulation Morpholines / chemistry Neoplasms, Experimental Phosphatidylinositol 3-Kinases / metabolism Phosphorylation Piperazines / chemistry Purines / chemical synthesis pharmacology
来 源:
DOI:10.1016/j.bioorg.2020.104344
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