关键词： Childhood Primary Hypertension Renin Angiotensin System Retinol Acyltransferase Spontaneously Hypertensive Rats Vitamin A Deficiency

Mesh ： Acyltransferases / metabolism Animals Biomarkers / metabolism Blood Pressure / physiology Child Female Humans Hypertension / diagnosis drug therapy metabolism Male Rats Rats, Inbred SHR Renin-Angiotensin System / drug effects physiology Tretinoin / metabolism Vitamin A / blood pharmacology Vitamin A Deficiency / diagnosis metabolism therapy Vitamins / blood pharmacology

来  源：   DOI：10.1080/10641963.2020.1833023   PDF(Sci-hub)

Abstract：
OBJECTIVE: Vitamin A (VA) deficiency triggers many diseases and is a worldwide nutrition problem. The Retinol acyltransferase (LRAT) is an indicator of VA storage function, and the relationship between LRAT and blood pressure level and the regulation mechanism will be elucidated.
METHODS: 160 children aged 6-12 years were included, and the serum VA and, the transcription levels of LRAT and RARs, were measured. Spontaneously hypertensive rats (SHRs) and WKY rats were treated with VA deficiency (VAD) or normal (VAN) fodder for 20 weeks. LRAT, retinoic acid, renin angiotensin system (RAS) biomarkers, and the structure and function of the heart for SHRs were measured.
RESULTS: The serum retinol and serum retinol/BMI levels were lower in children in the low LRAT group (LRATCONCLUSIONS: LRAT may be an important biomarker of vitamin A deficiency in target organs and may regulate BP by affecting RAS biomarkers.
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