Bullous Pemphigoid: Trigger and Predisposing Factors.

大疱性类天疱疮 ： 触发因素和诱发因素。

• 影响指数: 6.064
• 发表时间: 10 2020 10
• 来源期刊: Biomolecules
• DOI: 10.3390/biom10101432
• PMID: 33050407
• 文章类型: Journal Article
• 作者列表: Moro F,Fania L,Sinagra JLM,Salemme A,Di Zenzo G

关键词: autoimmune bullous disease; bullous pemphigoid; etiopathogenesis; predisposing factors; trigger factors

Mesh: Causality; Comorbidity; Disease Susceptibility; Drug-Related Side Effects and Adverse Reactions / complications diagnosis epidemiology; Gene-Environment Interaction; Genetic Predisposition to Disease; HLA Antigens / genetics; Humans; Infections / complications epidemiology; Pemphigoid, Bullous / diagnosis epidemiology etiology; Prognosis; Risk Factors

Abstract

Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and trigger factors. Several trigger factors, such as drugs, thermal or electrical burns, surgical procedures, trauma, ultraviolet irradiation, radiotherapy, chemical preparations, transplants, and infections may induce or exacerbate BP disease. Identification of predisposing and trigger factors can increase the understanding of BP pathogenesis. Furthermore, an accurate anamnesis focused on the recognition of a possible trigger factor can improve prognosis by promptly removing it.

摘要

大疱性类天疱疮（BP）是最常见的自身免疫性表皮下起泡疾病，由针对两种半网粒蛋白BP180和BP230的自身抗体引起。其发病机制取决于诱发因素之间的相互作用，如人类白细胞抗原（HLA）基因，合并症,老化，和触发因素。几个触发因素，比如毒品，热或电烧伤，外科手术,创伤,紫外线照射,放射治疗,化学制剂,移植,和感染可能诱发或加剧BP疾病。确定诱发因素和触发因素可以增加对BP发病机制的理解。此外，集中于识别可能的触发因素的准确回忆可以通过及时去除来改善预后.