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Abstract：
OBJECTIVE: We compared the effects of unilateral and bilateral salpingectomy for hydrosalpinx on ovarian function, oocyte retrieval, and embryogenesis.
METHODS: We retrospectively examined the hospital records of 109 women with unilateral hydrosalpinx and 57 women with bilateral hydrosalpinges who had undergone in vitro fertilization (IVF) treatment (280 oocyte retrieval cycles) between January 2011 and December 2018. We compared age at oocyte retrieval, level of anti-Müllerian hormone (AMH) measured within 1 year of oocyte retrieval, duration of infertility, number of previous IVF treatments, level of follicle stimulating hormone, total gonadotropin dose, number of oocytes retrieved, fertilization rate, blastocyst formation rate, and peak serum estrogen concentration. This study was approved by the institutional review board.
RESULTS: Of the women with unilateral hydrosalpinx, no significant differences were observed in ovarian response, rate of fertilization or rate of blastocyst production between the 21 women (24 cycles) who had undergone unilateral salpingectomy and the 88 women (146 cycles) who had not. Of the women with bilateral hydrosalpinges, the 13 (24 cycles) who had undergone bilateral salpingectomy had slightly lower AMH levels and significantly fewer oocytes retrieved (5.5 ± 3.9 vs 8.3 ± 5.5; P = .0068) than the 44 women (86 cycles) who had not had a salpingectomy. Women who had undergone bilateral salpingectomy also had significantly lower peak serum estrogen concentrations than those who had not undergone salpingectomy (1876.1 ± 765.9 vs 2489.5 ± 1551.4; P = .009).
CONCLUSIONS: In women with hydrosalpinx, bilateral salpingectomy may reduce ovarian function and response to gonadotropins, especially the number of oocytes retrieved. Unilateral salpingectomy does not have these effects.
METHODS: We retrospectively examined the hospital records of 109 women with unilateral hydrosalpinx and 57 women with bilateral hydrosalpinges who had undergone in vitro fertilization (IVF) treatment (280 oocyte retrieval cycles) between January 2011 and December 2018. We compared age at oocyte retrieval, level of anti-Müllerian hormone (AMH) measured within 1 year of oocyte retrieval, duration of infertility, number of previous IVF treatments, level of follicle stimulating hormone, total gonadotropin dose, number of oocytes retrieved, fertilization rate, blastocyst formation rate, and peak serum estrogen concentration. This study was approved by the institutional review board.
RESULTS: Of the women with unilateral hydrosalpinx, no significant differences were observed in ovarian response, rate of fertilization or rate of blastocyst production between the 21 women (24 cycles) who had undergone unilateral salpingectomy and the 88 women (146 cycles) who had not. Of the women with bilateral hydrosalpinges, the 13 (24 cycles) who had undergone bilateral salpingectomy had slightly lower AMH levels and significantly fewer oocytes retrieved (5.5 ± 3.9 vs 8.3 ± 5.5; P = .0068) than the 44 women (86 cycles) who had not had a salpingectomy. Women who had undergone bilateral salpingectomy also had significantly lower peak serum estrogen concentrations than those who had not undergone salpingectomy (1876.1 ± 765.9 vs 2489.5 ± 1551.4; P = .009).
CONCLUSIONS: In women with hydrosalpinx, bilateral salpingectomy may reduce ovarian function and response to gonadotropins, especially the number of oocytes retrieved. Unilateral salpingectomy does not have these effects.
摘要：
目的：我们比较了单侧和双侧输卵管切除术治疗输卵管积水对卵巢功能的影响，取卵,和胚胎发生。
方法：我们回顾性检查了2011年1月至2018年12月接受体外受精（IVF）治疗（280个卵母细胞取出周期）的109例单侧输卵管积水妇女和57例双侧输卵管积水妇女的医院记录。我们比较了取卵时的年龄，在取卵1年内测量的抗苗勒管激素（AMH）水平，不孕的持续时间，先前IVF治疗的数量，促卵泡激素水平,总促性腺激素剂量，回收的卵母细胞数量，受精率,囊胚形成率,和峰值血清雌激素浓度。这项研究得到了机构审查委员会的批准。
结果：单侧输卵管积水的妇女，在卵巢反应中没有观察到显著差异，接受单侧输卵管切除术的21名女性(24个周期)和未接受单侧输卵管切除术的88名女性(146个周期)的受精率或囊胚产生率。在双侧输卵管积水的女性中，与未进行双侧输卵管切除术的44例女性(86个周期)相比,接受双侧输卵管切除术的13例(24个周期)的AMH水平略低,并且获得的卵母细胞数量显著减少(5.5±3.9vs8.3±5.5;P=.0068).接受双侧输卵管切除术的女性血清雌激素峰值浓度也明显低于未接受输卵管切除术的女性（1876.1±765.9vs2489.5±1551.4；P=.009）。
结论：在输卵管积水的女性中，双侧输卵管切除术可能降低卵巢功能和对促性腺激素的反应，尤其是回收的卵母细胞数量。单侧输卵管切除术没有这些影响。
方法：我们回顾性检查了2011年1月至2018年12月接受体外受精（IVF）治疗（280个卵母细胞取出周期）的109例单侧输卵管积水妇女和57例双侧输卵管积水妇女的医院记录。我们比较了取卵时的年龄，在取卵1年内测量的抗苗勒管激素（AMH）水平，不孕的持续时间，先前IVF治疗的数量，促卵泡激素水平,总促性腺激素剂量，回收的卵母细胞数量，受精率,囊胚形成率,和峰值血清雌激素浓度。这项研究得到了机构审查委员会的批准。
结果：单侧输卵管积水的妇女，在卵巢反应中没有观察到显著差异，接受单侧输卵管切除术的21名女性(24个周期)和未接受单侧输卵管切除术的88名女性(146个周期)的受精率或囊胚产生率。在双侧输卵管积水的女性中，与未进行双侧输卵管切除术的44例女性(86个周期)相比,接受双侧输卵管切除术的13例(24个周期)的AMH水平略低,并且获得的卵母细胞数量显著减少(5.5±3.9vs8.3±5.5;P=.0068).接受双侧输卵管切除术的女性血清雌激素峰值浓度也明显低于未接受输卵管切除术的女性（1876.1±765.9vs2489.5±1551.4；P=.009）。
结论：在输卵管积水的女性中，双侧输卵管切除术可能降低卵巢功能和对促性腺激素的反应，尤其是回收的卵母细胞数量。单侧输卵管切除术没有这些影响。
