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Abstract：
Adult-onset inflammatory linear verrucous epidermal nevus (ILVEN) is an uncommon cutaneous disease compared to childhood-onset ILVEN. The typical histopathologic features are alternating parakeratosis and orthokeratosis with an absent granular layer underneath parakeratosis, in contrast to a thickened granular layer below the foci of orthokeratosis in psoriasiform epidermal hyperplasia. Herein, we present a 49-year-old woman with typical clinical and histopathologic characteristics of adult-onset ILVEN, including linear arrangement of thick scaly papules and plaques localized on the medial side of her right leg, ankle, and foot. Immunohistochemical studies included involucrin, Ki-67, and keratin-10. Compared to the staining pattern in psoriasis, the expression of involucrin in this case was of lower intensity and localized to upper epidermal layers with relatively less extensive staining beneath regions of parakeratosis as compared to orthokeratosis; Ki-67 showed lower basal layer proliferative activity; and keratin-10 showed a greater intensity of staining within suprabasal epidermis.
摘要：
成人发作的炎性线状疣状表皮痣(ILVEN)与儿童发作的ILVEN相比是一种少见的皮肤病。典型的组织病理学特征是交替出现角化不全和角化矫正，角化不全下方无颗粒层，与银屑病样表皮增生中角膜塑形病灶下方增厚的颗粒层相反。在这里，我们介绍了一个49岁的女性，具有典型的成年发病ILVEN的临床和组织病理学特征，包括位于右腿内侧的厚鳞片状丘疹和斑块的线性排列，脚踝,和脚。免疫组织化学研究包括总蛋白，Ki-67和角蛋白-10。与牛皮癣的染色模式相比，在这种情况下，与角化矫正器相比，总蛋白的表达强度较低，并且定位于上表皮层，在角化不全区域下的染色相对较少；Ki-67显示较低的基底层增殖活性；角蛋白10在鼻上表皮内显示较大的染色强度。
