METHODS: Patients who underwent surgery for stage 0-III breast cancer July 2010-March 2017 were identified retrospectively in a Japanese nationwide inpatient database. Multinomial logistic regression analyses adjusting for patient\'s age were conducted to compare the outcomes among five BMI groups: < 18.5 kg/m2 (n = 31,724; 9.3%), 18.5-24.9 kg/m2 (n = 218,244; 64.3%), 25.0-29.9 kg/m2 (n = 69,813; 20.6%), 30.0-34.9 kg/m2 (n = 16,052; 4.7%), and ≥ 35.0 kg/m2 (n = 3716; 1.1%). The outcomes were the quadrant and side of the breast where tumors were detected.
RESULTS: In total, about half of the patients had breast cancer in the upper-outer quadrant (49.7%) and in the left breast (51.1%). In the multinomial analysis, BMI ≥ 25.0 kg/m2 was associated with the occurrence of breast cancer in the upper-inner and lower-outer quadrants and in the central area, whereas BMI < 18.5 kg/m2 was associated with the occurrence of breast cancer in the central area only. The side of breast cancer did not differ significantly among the five BMI groups.
CONCLUSIONS: Localization of breast cancer was associated with BMI in this large nationwide cohort. The findings may benefit patients\' self-checks and doctors\' examinations, potentially resulting in early detection and treatment.
方法:2010年7月至2017年3月接受手术治疗的0-III期乳腺癌患者在日本全国住院患者数据库中进行回顾性鉴定。进行了调整患者年龄的多项逻辑回归分析,以比较五个BMI组之间的结果:<18.5kg/m2(n=31,724;9.3%),18.5-24.9kg/m2(n=218,244;64.3%),25.0-29.9kg/m2(n=69,813;20.6%),30.0-34.9kg/m2(n=16,052;4.7%),≥35.0kg/m2(n=3716;1.1%)。结果是检测到肿瘤的乳房的象限和侧面。
结果:总计,大约一半的患者在上-外象限(49.7%)和左乳腺(51.1%)患有乳腺癌.在多项式分析中,BMI≥25.0kg/m2与上内下外象限和中央区乳腺癌的发生有关,而BMI<18.5kg/m2仅与中央区乳腺癌的发生有关。乳腺癌的一面在五个BMI组中没有显着差异。
结论:在这个庞大的全国性队列中,乳腺癌的定位与BMI相关。这些发现可能有利于患者的自我检查和医生的检查,可能导致早期发现和治疗。