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Abstract：
OBJECTIVE: Neonatal infection by herpes simplex virus (HSV) 1 or 2 presents a devastating burden to new parents, due to the unpredictability of severe clinical outcomes, as well as the potential for lifelong reactivation. While just under half of neonatal HSV infections have mild clinical impacts akin to those observed in adults, the other half experience viral spread throughout the body (disseminated infection) and/or the brain (central nervous system infection).
CONCLUSIONS: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known factors of human host biology that contribute to the distinct neonatal outcomes of HSV infection.
RESULTS: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical path of a given neonatal infection.
CONCLUSIONS: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known factors of human host biology that contribute to the distinct neonatal outcomes of HSV infection.
RESULTS: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical path of a given neonatal infection.
摘要：
目的：新生儿单纯疱疹病毒（HSV）1或2感染给新父母带来了毁灭性的负担，由于严重临床结果的不可预测性，以及终身重新激活的潜力。虽然略低于一半的新生儿HSV感染具有与成人相似的轻微临床影响，另一半经历病毒传播全身（播散性感染）和/或大脑（中枢神经系统感染）。
结论：在这里，我们总结了有关临床诊断措施的现有数据，抗病毒治疗,以及导致HSV感染的不同新生儿结局的人类宿主生物学已知因素。
结果：然后，我们探讨了最近的新数据，即感染之间的病毒遗传多样性如何影响临床结果。进一步的研究对于建立这些早期发现并为我们辨别和/或预测给定新生儿感染的潜在临床路径的能力提供统计能力至关重要。
结论：在这里，我们总结了有关临床诊断措施的现有数据，抗病毒治疗,以及导致HSV感染的不同新生儿结局的人类宿主生物学已知因素。
结果：然后，我们探讨了最近的新数据，即感染之间的病毒遗传多样性如何影响临床结果。进一步的研究对于建立这些早期发现并为我们辨别和/或预测给定新生儿感染的潜在临床路径的能力提供统计能力至关重要。
