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Abstract：
UNASSIGNED: A head injury is a very dangerous condition that threatens human life. This study examines the use of caffeic acid phenethyl ester (CAPE) in reducing cerebral edema in cases of head injury. The purpose of this study is to demonstrate whether CAPE can improve various parameters related to the expression of Aquaporin-4 (AQP4) mRNA and the serum AQP4 levels in rat subjects.
UNASSIGNED: This is a randomized controlled study using a posttest-only control group design that uses experimental animals-specifically, male Rattus norvegicus (Sprague Dawley strain) rats aged 10-12 weeks and weighing 200-300 g. This study used a head injury model according to Marmarou (1994) with minor modifications to the animal model fixation tool. The parameters of the AQP4 mRNA were examined with real-time PCR, while serum AQP4 levels were examined with sandwich ELISA.
UNASSIGNED: The AQP4 mRNA expression in rats that were given CAPE was lower than those not given CAPE, both on the fourth and seventh days; serum AQP4 levels in rats that were given CAPE were also lower than those not given CAPE, both on the fourth and seventh days.
UNASSIGNED: Administration of CAPE in a rat model with head injury can reduce cerebral edema, mediated by AQP4.
UNASSIGNED: This is a randomized controlled study using a posttest-only control group design that uses experimental animals-specifically, male Rattus norvegicus (Sprague Dawley strain) rats aged 10-12 weeks and weighing 200-300 g. This study used a head injury model according to Marmarou (1994) with minor modifications to the animal model fixation tool. The parameters of the AQP4 mRNA were examined with real-time PCR, while serum AQP4 levels were examined with sandwich ELISA.
UNASSIGNED: The AQP4 mRNA expression in rats that were given CAPE was lower than those not given CAPE, both on the fourth and seventh days; serum AQP4 levels in rats that were given CAPE were also lower than those not given CAPE, both on the fourth and seventh days.
UNASSIGNED: Administration of CAPE in a rat model with head injury can reduce cerebral edema, mediated by AQP4.
摘要：
■头部受伤是一种非常危险的状况，威胁着人类的生命。这项研究检查了咖啡酸苯乙酯（CAPE）在减轻颅脑损伤病例中的脑水肿的用途。这项研究的目的是证明CAPE是否可以改善与大鼠受试者水通道蛋白4（AQP4）mRNA表达和血清AQP4水平相关的各种参数。
■这是一项随机对照研究，使用仅后测的对照组设计，使用实验动物-特别是，雄性Rattusnorvegicus（SpragueDawley品系）大鼠，年龄为10-12周，体重为200-300g。本研究使用了根据Marmarou（1994）的头部损伤模型，对动物模型固定工具进行了少量修改。用实时PCR检测AQP4mRNA的参数，同时用夹心ELISA检测血清AQP4水平。
■给予CAPE的大鼠AQP4mRNA表达低于未给予CAPE的大鼠,在第4天和第7天；给予CAPE的大鼠血清AQP4水平也低于未给予CAPE的大鼠，在第四天和第七天。
■在颅脑损伤大鼠模型中施用CAPE可以减轻脑水肿，AQP4介导。
■这是一项随机对照研究，使用仅后测的对照组设计，使用实验动物-特别是，雄性Rattusnorvegicus（SpragueDawley品系）大鼠，年龄为10-12周，体重为200-300g。本研究使用了根据Marmarou（1994）的头部损伤模型，对动物模型固定工具进行了少量修改。用实时PCR检测AQP4mRNA的参数，同时用夹心ELISA检测血清AQP4水平。
■给予CAPE的大鼠AQP4mRNA表达低于未给予CAPE的大鼠,在第4天和第7天；给予CAPE的大鼠血清AQP4水平也低于未给予CAPE的大鼠，在第四天和第七天。
■在颅脑损伤大鼠模型中施用CAPE可以减轻脑水肿，AQP4介导。
