PDF(Sci-hub)
Abstract：
BACKGROUND: Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its antiviral effects and the underlying molecular mechanisms exists.
UNASSIGNED: The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review.
CONCLUSIONS: Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.
UNASSIGNED: The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review.
CONCLUSIONS: Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.
摘要：
背景：大蒜（AlliumsativumL.）是一种自古以来就作为功能性食品和预防传染病的传统疗法在世界范围内食用的常见草药。大蒜及其活性有机硫化合物（OSC）已被报道在临床前和临床研究中减轻了许多病毒感染。然而,到目前为止，还没有关于其抗病毒作用和潜在分子机制的系统评价。
UNASSIGNED：这篇综述的目的是系统地总结大蒜及其OSCs的抗病毒作用的临床前和临床研究，并进一步分析支持这些抗病毒作用的机制的最新发现。PubMed,科克伦图书馆,搜索了GoogleScholar和ScienceDirect数据库，并在此评论中包含了截至2020年6月的文章。
结论：临床前数据表明，大蒜及其OSC具有针对不同人类的潜在抗病毒活性，通过阻断病毒进入宿主细胞的动植物病原病毒，抑制病毒RNA聚合酶，逆转录酶,DNA合成和立即早期基因1（IEG1）转录，以及通过下调细胞外信号调节激酶（ERK）/丝裂原活化蛋白激酶（MAPK）信号通路。病毒感染的缓解也被证明与大蒜及其OSC的免疫调节作用有关。临床研究进一步证明了大蒜通过增强免疫反应在预防人类广泛的病毒感染中的预防作用。这篇综述强调，大蒜具有显著的抗病毒活性，可用于预防性预防病毒感染。
UNASSIGNED：这篇综述的目的是系统地总结大蒜及其OSCs的抗病毒作用的临床前和临床研究，并进一步分析支持这些抗病毒作用的机制的最新发现。PubMed,科克伦图书馆,搜索了GoogleScholar和ScienceDirect数据库，并在此评论中包含了截至2020年6月的文章。
结论：临床前数据表明，大蒜及其OSC具有针对不同人类的潜在抗病毒活性，通过阻断病毒进入宿主细胞的动植物病原病毒，抑制病毒RNA聚合酶，逆转录酶,DNA合成和立即早期基因1（IEG1）转录，以及通过下调细胞外信号调节激酶（ERK）/丝裂原活化蛋白激酶（MAPK）信号通路。病毒感染的缓解也被证明与大蒜及其OSC的免疫调节作用有关。临床研究进一步证明了大蒜通过增强免疫反应在预防人类广泛的病毒感染中的预防作用。这篇综述强调，大蒜具有显著的抗病毒活性，可用于预防性预防病毒感染。
