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Abstract：
Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet. Cytochrome P450-derived LA metabolites 9,10-epoxyoctadecenoic acid (9,10-EpOME), 12,13-epoxyoctadecenoic acid (12,13-EpOME), 9,10-dihydroxy-12Z-octadecenoic acid (9,10-DiHOME) and 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) have been studied for their association with various disease states and biological functions. Previous studies of the EpOMEs and DiHOMEs have focused on their roles in cytotoxic processes, primarily in the inhibition of the neutrophil respiratory burst. More recent research has suggested the DiHOMEs may be important lipid mediators in pain perception, altered immune response and brown adipose tissue activation by cold and exercise. The purpose of this review is to summarize the current understanding of the physiological and pathophysiological roles and modes of action of the EpOMEs and DiHOMEs in health and disease.
摘要：
亚油酸（LA）是西方饮食中发现的最丰富的多不饱和脂肪酸。细胞色素P450衍生的LA代谢产物9,10-环氧十八烯酸（9,10-EpOME），12,13-环氧十八烯酸（12,13-EpOME），已经研究了9,10-二羟基-12Z-十八烯酸（9,10-DiHOME）和12,13-二羟基-9Z-十八烯酸（12,13-DiHOME）与各种疾病状态和生物学功能的关联。以前对EpOME和DiHOME的研究集中在它们在细胞毒性过程中的作用，主要表现在抑制中性粒细胞呼吸爆发。最近的研究表明，DiHOME可能是疼痛感知中重要的脂质介质，寒冷和运动改变了免疫反应和棕色脂肪组织的激活。这篇综述的目的是总结目前对EpOME和DiHOME在健康和疾病中的生理和病理生理作用和作用方式的理解。
