The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System.

内源性硫化氢和催产素系统在流体调节和心血管系统中的相互作用。

• 影响指数: 7.675
• 发表时间: Aug 2020 14
• 来源期刊: Antioxidants (Basel)
• DOI: 10.3390/antiox9080748
• PMID: 32823845
• 文章类型: Journal Article
• 作者列表: Denoix N,McCook O,Ecker S,Wang R,Waller C,Radermacher P,Merz T

关键词: cardiovascular; cystathionine γ-lyase; fluid regulation; hydrogen sulfide; oxytocin receptor; psychosomatic medicine

Abstract

The purpose of this review is to explore the parallel roles and interaction of hydrogen sulfide (H2S) and oxytocin (OT) in cardiovascular regulation and fluid homeostasis. Their interaction has been recently reported to be relevant during physical and psychological trauma. However, literature reports on H2S in physical trauma and OT in psychological trauma are abundant, whereas available information regarding H2S in psychological trauma and OT in physical trauma is much more limited. This review summarizes recent direct and indirect evidence of the interaction of the two systems and their convergence in downstream nitric oxide-dependent signaling pathways during various types of trauma, in an effort to better understand biological correlates of psychosomatic interdependencies.

摘要

这篇综述的目的是探讨硫化氢（H2S）和催产素（OT）在心血管调节和体液稳态中的平行作用和相互作用。最近据报道，他们的相互作用在身体和心理创伤期间是相关的。然而,关于身体创伤中的H2S和心理创伤中的OT的文献报道很多，而有关心理创伤中H2S和身体创伤中OT的可用信息则有限得多。这篇综述总结了最近的直接和间接证据，证明了两种系统在各种类型的创伤中相互作用及其在下游一氧化氮依赖性信号通路中的融合。为了更好地理解心身相互依存的生物学相关性。