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Abstract：
To explores the prevalence of autoantibodies (zinc transporter 8 autoantibodies (ZnT8A), antibodies to insulin (IAAs), glutamic acid decarboxylase autoantibody (GAD65)), the relation of the type of positive autoantibody and the number of positive autoantibodies with the glycemic and lipid profile of the patients with LADA (Latent Autoimmune Diabetes in Adults) and compares it to the metabolic profile of patients presenting with type 2 diabetes (T2DM).
263 patients with T2DM were recruited for this cross-sectional study in Tehran, Iran. Data from patients included complete medical history, GAD65, ZnT8A, IAA and routine metabolic laboratory workup. Assay for autoantibodies were conducted using ELISA kits. The association between autoantibodies and glycemic and lipid profile of patients with diabetes was assessed using univariate and multivariate regression analysis.
Our study revealed that among 263 patients with T2DM, 29 (11%) cases were positive for IAAs, 9 (3.4%) for ZnT8A, and 12 (4.6%) for GAD65. Six (2.3%) of the patients had triple positive antibodies. Patients with positive results were younger, had lower body mass index (BMI), c-peptide, triglyceride, low-density lipoprotein (LDL), and higher high-density lipoprotein (HDL), HbA1c and fasting blood glucose (FBG) levels. Triple antibody positivity was significantly associated with lower levels of C-Peptide, Triglycerides, FBG, and HbA1c compared to triple negative antibodies.
Patients with LADA positive for either of the autoantibodies (GAD65, ZnT8 and IAA) presented with worse glycemic control. Measurement of these autoantibodies can assist in discrimination of these patients and help with earlier control of glycemic profile.
263 patients with T2DM were recruited for this cross-sectional study in Tehran, Iran. Data from patients included complete medical history, GAD65, ZnT8A, IAA and routine metabolic laboratory workup. Assay for autoantibodies were conducted using ELISA kits. The association between autoantibodies and glycemic and lipid profile of patients with diabetes was assessed using univariate and multivariate regression analysis.
Our study revealed that among 263 patients with T2DM, 29 (11%) cases were positive for IAAs, 9 (3.4%) for ZnT8A, and 12 (4.6%) for GAD65. Six (2.3%) of the patients had triple positive antibodies. Patients with positive results were younger, had lower body mass index (BMI), c-peptide, triglyceride, low-density lipoprotein (LDL), and higher high-density lipoprotein (HDL), HbA1c and fasting blood glucose (FBG) levels. Triple antibody positivity was significantly associated with lower levels of C-Peptide, Triglycerides, FBG, and HbA1c compared to triple negative antibodies.
Patients with LADA positive for either of the autoantibodies (GAD65, ZnT8 and IAA) presented with worse glycemic control. Measurement of these autoantibodies can assist in discrimination of these patients and help with earlier control of glycemic profile.
摘要：
探讨自身抗体(锌转运蛋白8自身抗体(ZnT8A)，胰岛素抗体（IAAs），谷氨酸脱羧酶自身抗体（GAD65），阳性自身抗体的类型和阳性自身抗体的数量与LADA（成人隐匿性自身免疫性糖尿病）患者的血糖和血脂状况的关系，并将其与2型糖尿病（T2DM）患者的代谢状况进行比较。
在德黑兰招募了263名T2DM患者进行这项横断面研究，伊朗。患者的数据包括完整的病史，GAD65,ZnT8A,IAA和常规代谢实验室检查。使用ELISA试剂盒进行自身抗体的测定。使用单变量和多变量回归分析评估糖尿病患者自身抗体与血糖和血脂之间的关联。
我们的研究表明，在263名T2DM患者中，29例(11%)IAAs阳性，9（3.4%）对于ZnT8A，GAD65为12（4.6%）。六名（2.3％）的患者具有三重阳性抗体。阳性结果的患者更年轻，体重指数（BMI）较低，c-肽，甘油三酯，低密度脂蛋白（LDL），高密度脂蛋白（HDL），HbA1c和空腹血糖（FBG）水平。三重抗体阳性与C肽水平降低显着相关，甘油三酯,FBG,和HbA1c与三阴性抗体相比。
对于任一自身抗体(GAD65、ZnT8和IAA)具有LADA阳性的患者呈现较差的血糖控制。这些自身抗体的测量可有助于区分这些患者并有助于早期控制血糖谱。
在德黑兰招募了263名T2DM患者进行这项横断面研究，伊朗。患者的数据包括完整的病史，GAD65,ZnT8A,IAA和常规代谢实验室检查。使用ELISA试剂盒进行自身抗体的测定。使用单变量和多变量回归分析评估糖尿病患者自身抗体与血糖和血脂之间的关联。
我们的研究表明，在263名T2DM患者中，29例(11%)IAAs阳性，9（3.4%）对于ZnT8A，GAD65为12（4.6%）。六名（2.3％）的患者具有三重阳性抗体。阳性结果的患者更年轻，体重指数（BMI）较低，c-肽，甘油三酯，低密度脂蛋白（LDL），高密度脂蛋白（HDL），HbA1c和空腹血糖（FBG）水平。三重抗体阳性与C肽水平降低显着相关，甘油三酯,FBG,和HbA1c与三阴性抗体相比。
对于任一自身抗体(GAD65、ZnT8和IAA)具有LADA阳性的患者呈现较差的血糖控制。这些自身抗体的测量可有助于区分这些患者并有助于早期控制血糖谱。
