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Abstract：
Studies in chickens suggest low intensity ambient lighting causes myopia. The purpose of this experiment was to examine the effects of low intensity ambient lighting (dim light) on normal refractive development in macaque monkeys. Seven infant rhesus monkeys were reared under dim light (room illumination level: ~55 lx) from 24 to ~310 days of age with otherwise unrestricted vision. Refractive error, corneal power, ocular axial dimensions, and choroidal thickness were measured in anesthetized animals at the onset of the experiment and periodically throughout the dim-light-rearing period, and were compared with those of normal-light-reared monkeys. We found that dim light did not produce myopia; instead, dim-light monkeys were hyperopic relative to normal-light monkeys (median refractive errors at ~155 days, OD: +3.13 D vs. +2.31 D; OS: +3.31D vs. +2.44 D; at ~310 days, OD: +2.75D vs. +1.78D, OS: +3.00D vs. +1.75D). In addition, dim-light rearing caused sustained thickening in the choroid, but it did not alter corneal power development, nor did it change the axial nature of the refractive errors. These results showed that, for rhesus monkeys and possibly other primates, low ambient lighting by itself is not necessarily myopiagenic, but might compromise the efficiency of emmetropization.
摘要：
对鸡的研究表明，低强度的环境照明会导致近视。该实验的目的是检查低强度环境照明(暗光)对猕猴正常屈光发育的影响。在24天至310天龄的昏暗光线下（房间照明水平：〜55lx）饲养了7只恒河猴，否则视力不受限制。折射错误，角膜力，眼轴尺寸，和脉络膜厚度是在实验开始时在麻醉动物中测量的，并且在整个昏光饲养期间定期测量，并与正常光饲养的猴子进行了比较。我们发现昏暗的光线不会产生近视；相反，弱光猴相对于正常光猴是远视的（约155天的中位屈光不正，OD：+3.13Dvs.+2.31D;操作系统:+3.31Dvs.+2.44D；在~310天，OD：+2.75Dvs.+1.78D,操作系统：+3.00Dvs.+1.75D）。此外,暗光饲养导致脉络膜持续增厚，但它并没有改变角膜力量的发展，它也没有改变屈光不正的轴向性质。这些结果表明,对于恒河猴和其他灵长类动物来说，低环境照明本身不一定是近视性的，但可能会损害正视化的效率。
