关键词: ancient nevus angiomatoid Spitz congenital melanocytic nevi malignant melanoma proliferative nodule

Mesh : African Americans / ethnology Angiomatosis / pathology Biopsy Cell Proliferation Child Diagnosis, Differential Gene Expression Profiling / methods Histones / metabolism Humans Hyperpigmentation / pathology Immunohistochemistry / methods Knee / pathology Male Melanoma / pathology Nevus, Pigmented / congenital diagnosis metabolism pathology surgery SOXE Transcription Factors / metabolism Skin Neoplasms / diagnosis metabolism pathology surgery Tumor Suppressor Proteins / metabolism Ubiquitin Thiolesterase / metabolism

来  源:   DOI:10.1111/cup.13840   PDF(Sci-hub)

Abstract:
Proliferative nodules arising within congenital melanocytic nevi often present a diagnostic challenge given a close resemblance to melanoma. Several morphologic variants have been characterized. In difficult cases, ancillary molecular tests can be used to better exclude the possibility of malignant degeneration. Herein, we report a case of an unusual proliferative nodule with overlapping features of angiomatoid Spitz tumor and ancient melanocytic nevus, which demonstrated normal findings on both chromosomal microarray and a gene expression profiling assay.
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