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Abstract：
To comparatively explore the differences between 18F-Flurpiridaz and 13N-NH3·H2O PET/CT myocardial perfusion imaging in miniature pigs.
Ten Bama minipigs were divided into normal group and myocardial infarction group. The changes of the ratio of left ventricular myocardium to main organs with time were calculated and the best imaging time was confirmed for 18F-Flurpiridaz imaging in normal group. The image quality score, summed rest score(SRS), Extend, total perfusion deficit(TPD) and left ventricle ejection fraction(LVEF) were respectively compared for 18F-Flurpiridaz and 13N-NH3·H2O in infarction group.
18F-Flurpiridaz was rapid distributed in myocardium, and the background counts of cardiac cavity were very low, and no obvious interference extracardiac radioactivity was observed. The radioactive ratio of the left ventricular myocardium to cardiac blood pool and adjacent liver were high. Compared with 13N-NH3·H2O, there were no significant differences in functional parameters, including SRS, Extend, TPD and LVEF.
The results preliminaryly show that 18F-FIurpiridaz is a promising positron MPI agent with good image quality, ability of accurately evaluating cardiac function, and also convenience for application.
Ten Bama minipigs were divided into normal group and myocardial infarction group. The changes of the ratio of left ventricular myocardium to main organs with time were calculated and the best imaging time was confirmed for 18F-Flurpiridaz imaging in normal group. The image quality score, summed rest score(SRS), Extend, total perfusion deficit(TPD) and left ventricle ejection fraction(LVEF) were respectively compared for 18F-Flurpiridaz and 13N-NH3·H2O in infarction group.
18F-Flurpiridaz was rapid distributed in myocardium, and the background counts of cardiac cavity were very low, and no obvious interference extracardiac radioactivity was observed. The radioactive ratio of the left ventricular myocardium to cardiac blood pool and adjacent liver were high. Compared with 13N-NH3·H2O, there were no significant differences in functional parameters, including SRS, Extend, TPD and LVEF.
The results preliminaryly show that 18F-FIurpiridaz is a promising positron MPI agent with good image quality, ability of accurately evaluating cardiac function, and also convenience for application.
摘要：
比较研究小型猪18F-Flurpiridaz和13N-NH3·H2OPET/CT心肌灌注显像的差异。
将10只巴马小型猪分为正常组和心肌梗死组。计算左心室心肌与主要器官的比值随时间的变化，并确定正常组18F-Flurpiridaz成像的最佳成像时间。图像质量得分，总休息分数(SRS)，延伸,分别比较梗死组18F-Flurpiridaz和13N-NH3·H2O的总灌注缺陷（TPD）和左心室射血分数（LVEF）。
18F-Flurpiridaz在心肌中快速分布，心脏腔的背景计数非常低，未观察到明显的干扰心外放射性。左心室心肌与心脏血池和邻近肝脏的放射性比率较高。与13N-NH3·H2O相比，功能参数没有显着差异，包括SRS,延伸,TPD和LVEF。
初步结果表明，18F-FIurpiridaz是一种有前途的正电子MPI剂，具有良好的图像质量，准确评估心功能的能力，也便于应用。
将10只巴马小型猪分为正常组和心肌梗死组。计算左心室心肌与主要器官的比值随时间的变化，并确定正常组18F-Flurpiridaz成像的最佳成像时间。图像质量得分，总休息分数(SRS)，延伸,分别比较梗死组18F-Flurpiridaz和13N-NH3·H2O的总灌注缺陷（TPD）和左心室射血分数（LVEF）。
18F-Flurpiridaz在心肌中快速分布，心脏腔的背景计数非常低，未观察到明显的干扰心外放射性。左心室心肌与心脏血池和邻近肝脏的放射性比率较高。与13N-NH3·H2O相比，功能参数没有显着差异，包括SRS,延伸,TPD和LVEF。
初步结果表明，18F-FIurpiridaz是一种有前途的正电子MPI剂，具有良好的图像质量，准确评估心功能的能力，也便于应用。
