Asymptomatic pulmonary penicilliosis with a lung mass in an HIV-infected patient.

HIV 感染患者无症状性肺青霉病伴肺部肿块。

• 发表时间: Jul 2020
• 来源期刊: J Gen Fam Med
• DOI: 10.1002/jgf2.325
• PMID: 32742907
• 文章类型: Case Reports
• 作者列表: Nishikubo M,Doi A,Takegawa H,Yamashita D,Ohira J,Nishioka H

关键词: HIV; Penicillium marneffei; asymptomatic respiratory infection; lung mass

Abstract

Penicillium marneffei (Talaromyces marneffei) infection sometimes occurs in HIV-infected patients in South-East Asia. However, reports on asymptomatic cases are rare. Herein, we report a case of a 27-year-old Burmese HIV-positive woman with pulmonary penicilliosis. Chest radiography showed a lung mass; however, the patient did not have any respiratory symptoms. Cultures of bronchoalveolar lavage and lung tissue grew P marneffei. The patient was diagnosed with penicilliosis and successfully treated with amphotericin B and itraconazole. Our findings suggest that P marneffei infection should be considered in the differential diagnosis of a lung mass in HIV-infected patients, even when asymptomatic for respiratory symptoms.

摘要

马尔尼菲青霉菌（Talaromycesmarneffei）感染有时发生在东南亚的HIV感染患者中。然而,有关无症状病例的报告很少见。在这里，我们报告一例27岁的缅甸HIV阳性女性肺部青霉病。胸部X线检查显示肺部肿块；然而，患者没有任何呼吸道症状。支气管肺泡灌洗和肺组织培养物生长马内菲。该患者被诊断为青霉病，并成功使用两性霉素B和伊曲康唑治疗。我们的发现表明，在HIV感染患者的肺部肿块的鉴别诊断中，应考虑马尼菲感染。即使没有呼吸道症状。