Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations.

• 影响指数: 3.243
• 发表时间: 02 2021
• 来源期刊: Parasitology
• DOI: 10.1017/S0031182020001262
• PMID: 32729438
• 文章类型: Guideline
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Ansdell V,Kramer KJ,McMillan JK,Gosnell WL,Murphy GS,Meyer BC,Blalock EU,Yates J,Lteif L,Smith OA,Melish M

关键词: Diagnosis; Neuroangiostrongyliais; Treatment

Mesh: Adrenal Cortex Hormones / administration & dosage; Albendazole / administration & dosage; Angiostrongylus cantonensis / physiology; Animals; Anthelmintics / administration & dosage; Hawaii; Humans; Strongylida Infections / diagnosis drug therapy

Abstract

A subcommittee of the Hawaii Governor\'s Joint Task Force on Rat Lungworm Disease developed preliminary guidelines for the diagnosis and treatment of neuroangiostrongyliasis (NAS) in 2018 (Guidelines, 2018). This paper reviews the main points of those guidelines and provides updates in areas where our understanding of the disease has increased. The diagnosis of NAS is described, including confirmation of infection by real-time polymerase chain reaction (RTi-PCR) to detect parasite DNA in the central nervous system (CNS). The treatment literature is reviewed with recommendations for the use of corticosteroids and the anthelminthic drug albendazole. Long-term sequelae of NAS are discussed and recommendations for future research are proposed.