Abstract：
BACKGROUND: Patient-reported outcomes (PROs) have been widely accepted in western countries. However, limited attention has been given to PROs in China due to a lack of research on the agreement between doctors\' and patients\' reports of adverse events. This study aims to reveal the perception gap of chemotherapy-induced adverse events between doctors and cancer patients in China.
METHODS: An observational study was administered at Sun Yat-Sen University Cancer Center (SYSUCC). Totally, 200 adult cancer patients undergoing chemotherapy participated. Patient reports were collected by nurses via telephone. Doctor reports were collected by nurses based on their medical records. The agreement between doctors and patients was analyzed by Cohen\'s κ.
RESULTS: Agreement between doctors and patients varied among different symptoms: 0.26 for nausea/vomiting, 0.49 for constipation, 0.63 for diarrhea, 0.65 for general pain, and 0.76 for rash. Doctors\' underreporting rates were 70% for nausea/vomiting, 50% for diarrhea, 38% for rash, 33% for constipation, and 29% for general pain.
CONCLUSIONS: The perception gap of chemotherapy-induced adverse events between doctors and patients exists in China, especially regarding subjective symptoms. Introduction of PROs in both clinical trials and routine clinical practice should be considered in China.
METHODS: An observational study was administered at Sun Yat-Sen University Cancer Center (SYSUCC). Totally, 200 adult cancer patients undergoing chemotherapy participated. Patient reports were collected by nurses via telephone. Doctor reports were collected by nurses based on their medical records. The agreement between doctors and patients was analyzed by Cohen\'s κ.
RESULTS: Agreement between doctors and patients varied among different symptoms: 0.26 for nausea/vomiting, 0.49 for constipation, 0.63 for diarrhea, 0.65 for general pain, and 0.76 for rash. Doctors\' underreporting rates were 70% for nausea/vomiting, 50% for diarrhea, 38% for rash, 33% for constipation, and 29% for general pain.
CONCLUSIONS: The perception gap of chemotherapy-induced adverse events between doctors and patients exists in China, especially regarding subjective symptoms. Introduction of PROs in both clinical trials and routine clinical practice should be considered in China.
摘要：
背景：患者报告的结果（PRO）在西方国家已被广泛接受。然而,由于缺乏关于医生和患者之间不良事件报告协议的研究，中国对PRO的关注有限。本研究旨在揭示中国医生和癌症患者对化疗不良事件的认知差距。
方法：一项观察性研究在中山大学肿瘤中心（SYSUCC）进行。完全正确,200名接受化疗的成年癌症患者参加。患者报告由护士通过电话收集。医生报告是由护士根据他们的医疗记录收集的。医生和患者之间的协议由科恩的κ分析。
结果：医生和患者之间的协议因不同症状而异：恶心/呕吐为0.26，便秘为0.49，0.63表示腹泻，一般疼痛为0.65，皮疹为0.76。医生对恶心/呕吐的漏报率为70%，50%为腹泻，38%为皮疹，33%为便秘，29％为一般疼痛。
结论：在中国，医生和患者对化疗引起的不良事件的认知存在差距，尤其是主观症状。在中国应考虑在临床试验和常规临床实践中引入PROs。
方法：一项观察性研究在中山大学肿瘤中心（SYSUCC）进行。完全正确,200名接受化疗的成年癌症患者参加。患者报告由护士通过电话收集。医生报告是由护士根据他们的医疗记录收集的。医生和患者之间的协议由科恩的κ分析。
结果：医生和患者之间的协议因不同症状而异：恶心/呕吐为0.26，便秘为0.49，0.63表示腹泻，一般疼痛为0.65，皮疹为0.76。医生对恶心/呕吐的漏报率为70%，50%为腹泻，38%为皮疹，33%为便秘，29％为一般疼痛。
结论：在中国，医生和患者对化疗引起的不良事件的认知存在差距，尤其是主观症状。在中国应考虑在临床试验和常规临床实践中引入PROs。
