关键词: SARS-CoV-2 infection age-related immune response childhood COVID-19 pediatric COVID-19

Mesh : Adaptive Immunity Adult Aging / immunology COVID-19 / immunology Child Humans Immunity, Innate SARS-CoV-2 / physiology Systemic Inflammatory Response Syndrome / immunology Virus Internalization

来  源:   DOI:10.1002/ppul.24981   PDF(Sci-hub)

Abstract:
The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.
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